Literature DB >> 17126371

How has legislation restricting paracetamol pack size affected patterns of deprivation related inequalities in self-harm in Scotland?

D R Gorman1, M Bain, J H C Inglis, D Murphy, D N Bateman.   

Abstract

OBJECTIVE: To describe how changes in legislation to control sales and thus restrict the general availability of paracetamol have affected deprivation-related inequalities in deliberate self-harm associated with the drug in Scotland. DESIGN AND
SETTING: A descriptive analysis of routine death and hospital discharge data for the entire Scottish population between 1995 and 2002. PARTICIPANTS: Patients in Scotland admitted to hospital with a diagnosis of poisoning and deaths in Scotland due to poisoning 1995-2002. OUTCOME MEASURES: Changes in mortality and overdose rates by deprivation quintile, and case fatality rates due to poisoning involving paracetamol.
RESULTS: Rates of overdose involving paracetamol, while much higher in disadvantaged quintiles, fell in each deprivation quintile following the 1998 legislation. They then returned to levels similar, or above those in the mid 1990s. All quintiles were affected to a similar extent with the relationship between them remaining constant over time. Case fatality rates were significantly higher in more disadvantaged quintiles.
CONCLUSIONS: Marked inequalities exist in paracetamol related harm in Scotland. The most disadvantaged groups (both male and female) have higher overdose and death rates, as well as higher case fatality rates. Following the restrictions all social groups saw similar reductions in paracetamol related harm. This effect has been short-lived and rates have returned to pre-legislation levels. Legislation has not permanently affected overall use of paracetamol in overdose in Scotland or reduced the proportion of patients taking paracetamol as a component of the overdose in the longer term. An important public health policy has failed to achieve its objective and it is not clear why. We need a better understanding of why this measure had only short-term benefits if its full potential is to be achieved.

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Year:  2006        PMID: 17126371     DOI: 10.1016/j.puhe.2006.08.014

Source DB:  PubMed          Journal:  Public Health        ISSN: 0033-3506            Impact factor:   2.427


  3 in total

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Authors:  N Pakravan; K J Simpson; W S Waring; C M Bates; D N Bateman
Journal:  Eur J Clin Pharmacol       Date:  2008-10-29       Impact factor: 2.953

2.  Detailed analyses of self-poisoning episodes presenting to a large regional teaching hospital in the UK.

Authors:  Katherine Prescott; Richard Stratton; Anette Freyer; Ian Hall; Ivan Le Jeune
Journal:  Br J Clin Pharmacol       Date:  2009-08       Impact factor: 4.335

3.  Measuring the impact of medicines regulatory interventions - Systematic review and methodological considerations.

Authors:  Thomas Goedecke; Daniel R Morales; Alexandra Pacurariu; Xavier Kurz
Journal:  Br J Clin Pharmacol       Date:  2017-12-20       Impact factor: 4.335

  3 in total

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