OBJECTIVE: With an incidence of up to 5% in the general population, genital malformations are a frequent clinical occurrence. The aim of this study was to assess whether a connection could be demonstrated between various degrees of severity of genital malformations and associated abnormalities. DESIGN: All patients were classified using the Vagina, Cervix, Uterus, Adnex, and Associated Malformation (VCUAM) classification. SETTING: University hospital. PATIENT(S): Two hundred eleven premenopausal patients with female genital malformations. INTERVENTION(S): The patients underwent diagnostic workup for genital malformations using laparoscopy as well as hysteroscopy. Associated malformations were detected by either magnetic resonance imaging (MRI) or ultrasound. MAIN OUTCOME MEASURE(S): Demonstration of a connection between various degrees of severity of genital malformations and associated abnormalities. RESULT(S): In 72 cases (36%) out of 202 patients with uterine malformations (VCUAM U1-4) we found associated abnormalities. The predominant findings were alterations in the renal system. When vaginal abnormality (VCUAM V1-5) alone was taken into consideration, an associated developmental disturbance in the renal tract was found in 30% of cases (n = 32 from 107). CONCLUSION(S): A close connection was demonstrated between genital malformations and associated abnormalities. For this reason, the diagnostic workup in patients with malformations should always include the renal system. Depending on the severity of the clinical picture, examinations may need to be extended further.
OBJECTIVE: With an incidence of up to 5% in the general population, genital malformations are a frequent clinical occurrence. The aim of this study was to assess whether a connection could be demonstrated between various degrees of severity of genital malformations and associated abnormalities. DESIGN: All patients were classified using the Vagina, Cervix, Uterus, Adnex, and Associated Malformation (VCUAM) classification. SETTING: University hospital. PATIENT(S): Two hundred eleven premenopausal patients with female genital malformations. INTERVENTION(S): The patients underwent diagnostic workup for genital malformations using laparoscopy as well as hysteroscopy. Associated malformations were detected by either magnetic resonance imaging (MRI) or ultrasound. MAIN OUTCOME MEASURE(S): Demonstration of a connection between various degrees of severity of genital malformations and associated abnormalities. RESULT(S): In 72 cases (36%) out of 202 patients with uterine malformations (VCUAM U1-4) we found associated abnormalities. The predominant findings were alterations in the renal system. When vaginal abnormality (VCUAM V1-5) alone was taken into consideration, an associated developmental disturbance in the renal tract was found in 30% of cases (n = 32 from 107). CONCLUSION(S): A close connection was demonstrated between genital malformations and associated abnormalities. For this reason, the diagnostic workup in patients with malformations should always include the renal system. Depending on the severity of the clinical picture, examinations may need to be extended further.
Authors: Serena Nik-Zainal; Reiner Strick; Mekayla Storer; Ni Huang; Roland Rad; Lionel Willatt; Tomas Fitzgerald; Vicki Martin; Richard Sandford; Nigel P Carter; Andreas R Janecke; Stefan P Renner; Patricia G Oppelt; Peter Oppelt; Christine Schulze; Sara Brucker; Matthew Hurles; Matthias W Beckmann; Pamela L Strissel; Charles Shaw-Smith Journal: J Med Genet Date: 2011-01-28 Impact factor: 6.318
Authors: John S Wiener; Nina Huck; Anne-Sophie Blais; Mandy Rickard; Armando Lorenzo; Heather N McCaffrey Di Carlo; Margaret G Mueller; Raimund Stein Journal: World J Urol Date: 2020-04-23 Impact factor: 4.226
Authors: Peter Klimek; Miriam Klimek; Ulf Kessler; Valerie Oesch; Rainer Wolf; Enno Stranzinger; Michael D Mueller; Zacharias Zachariou Journal: J Med Case Rep Date: 2012-12-12
Authors: Sara Yvonne Brucker; Leonie-Sophia Pösch; Joachim Graf; Alexander N Sokolov; Norbert Schaeffeler; Andrea Kronenthaler; Hanna Hiltner; Anke Wagner; Esther Ueding; Monika A Rieger; Dorit Schöller; Diana Stefanescu; Kristin Katharina Rall; Diethelm Wallwiener; Elisabeth Simoes Journal: BMC Womens Health Date: 2020-06-29 Impact factor: 2.809