| Literature DB >> 17126079 |
Xutao Deng1, Huimin Geng, Dhundy R Bastola, Hesham H Ali.
Abstract
We present a new method, link-test, to select prostate cancer biomarkers from SELDI mass spectrometry and microarray data sets. Biomarkers selected by link-test are supported by data sets from both mRNA and protein levels, and therefore results in improved robustness. Link-test determines the level of significance of the association between a microarray marker and a specific mass spectrum marker by constructing background mass spectra distributions estimated by all human protein sequences in the SWISS-PROT database. The data set consist of both microarray and mass spectrometry data from prostate cancer patients and healthy controls. A list of statistically justified prostate cancer biomarkers is reported by link-test. Cross-validation results show high prediction accuracy using the identified biomarker panel. We also employ a text-mining approach with OMIM database to validate the cancer biomarkers. The study with link-test represents one of the first cross-platform studies of cancer biomarkers.Entities:
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Year: 2006 PMID： 17126079 PMCID： PMC1941704 DOI： 10.1016/j.compbiolchem.2006.09.002
Source DB: PubMed Journal: Comput Biol Chem ISSN： 1476-9271 Impact factor: 2.877