| Literature DB >> 17126019 |
Ioanna C Siskou1, Eleni A Rekka, Angeliki P Kourounakis, Michael C Chrysselis, Kariofyllis Tsiakitzis, Panos N Kourounakis.
Abstract
Six novel ibuprofen derivatives and related structures, incorporating a proline moiety and designed for neurodegenerative disorders, are studied. They possess anti-inflammatory properties and three of them inhibited lipoxygenase. One compound was found to inhibit cyclooxygenase (COX)-2 production in spleenocytes from arthritic rats. The HS-containing compounds are potent antioxidants and one of them protected against glutathione loss after cerebral ischemia/reperfusion. They demonstrated lipid-lowering ability and seem to acquire low gastrointestinal toxicity. Acetylcholinesterase inhibitory activity, found in two of these compounds, may be an asset to their actions.Entities:
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Year: 2006 PMID： 17126019 DOI： 10.1016/j.bmc.2006.10.056
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641