Literature DB >> 17125888

Synthesis and antimicrobial activity of 1-(4-aryl-2-thiazolyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives.

Ahmet Ozdemir1, Gülhan Turan-Zitouni, Zafer Asim Kaplancikli, Gilbert Revial, Kiymet Güven.   

Abstract

Several 1-(4-aryl-2-thiazolyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting substituted 3-(2-thienyl)-5-aryl-1-thiocarbamoyl-2-pyrazolines with phenacyl bromides in ethanol. The structures of the synthesized compounds were confirmed by (1)H NMR, (13)C NMR, and EIMS spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3704), Staphylococcus aureus (NRLL B-767), Salmonella typhimurium (NRRL B-4420), Bacillus cereus (NRRL B-3711), Streptococcus faecalis (NRRL B-14617), Aeromonas hydrophila (Ankara Uni. Fac. of Veterinary), Candida albicans and Candida glabrata (isolates obtained from Osmangazi Uni. Fac. of Medicine) were investigated. A significant level of activity was observed.

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Year:  2006        PMID： 17125888     DOI： 10.1016/j.ejmech.2006.10.001

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  10 in total

1.  Comparative DFT Computational Studies with Experimental Investigations for Novel Synthesized Fluorescent Pyrazoline Derivatives.

Authors:  Ahmad Saed Salim; Adel S Girgis; Altaf H Basta; Houssni El-Saied; Mohamed A Mohamed; Ahmad H Bedair
Journal:  J Fluoresc       Date:  2018-06-29       Impact factor: 2.217

2.  Application of butenonyl-C-glucosides in the synthesis of pyrazolinyl-, aminopyrimidinyl- and biphenyl methyl-β-D-C-glucopyranosides.

Authors:  Seerat Fatima; Vivek Parashar Pandey; Surendra Singh Bisht; Rama P Tripathi
Journal:  Mol Divers       Date:  2011-02-25       Impact factor: 2.943

3.  Synthesis and spectroscopic properties of novel fluorescent compounds containing bis-pyrazole ring.

Authors:  Tiegang Ren; Jie Wang; Guihui Li; Yongzhe Li
Journal:  J Fluoresc       Date:  2014-05-02       Impact factor: 2.217

4.  Synthesis and Antimicrobial Activity of 2-[2-(2,6-dichloro phenyl)amino]benzyl-3-(5-substituted phenyl-4,5-dihydro-1H-pyrazol-3-yl-amino)-6,8-dibromoquinazolin-4(3H)ones.

Authors:  Nb Patel; Jc Patel; Gg Barat
Journal:  J Young Pharm       Date:  2010-04

5.  4-{(E)-[2-(4-Iodo-but-oxy)benzyl-idene]amino}-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

Authors:  Hoong-Kun Fun; Madhukar Hemamalini; Abdullah M Asiri; Salman A Khan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-06-05

6.  Design, synthesis and antibacterial potential of 5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-1-substituted-4,5-dihydropyrazoles.

Authors:  Mohammed F El-Behairy; Tarek E Mazeed; Aida A El-Azzouny; Mohamed N Aboul-Enein
Journal:  Saudi Pharm J       Date:  2014-07-28       Impact factor: 4.330

7.  Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L.

Authors:  Neera Raghav; Ravinder Kaur
Journal:  Int J Biol Macromol       Date:  2015-07-18       Impact factor: 6.953

Review 8.  Recent advances in the therapeutic applications of pyrazolines.

Authors:  Mohamed R Shaaban; Abdelrahman S Mayhoub; Ahmad M Farag
Journal:  Expert Opin Ther Pat       Date:  2012-03-08       Impact factor: 6.674

9.  Facile synthesis and antimicrobial evaluation of some new heterocyclic compounds incorporating a biologically active sulfamoyl moiety.

Authors:  Elham S Darwish
Journal:  ScientificWorldJournal       Date:  2014-08-17

10.  Synthesis and Characterization of Some New Bis-Pyrazolyl-Thiazoles Incorporating the Thiophene Moiety as Potent Anti-Tumor Agents.

Authors:  Sobhi M Gomha; Mastoura M Edrees; Farag M A Altalbawy
Journal:  Int J Mol Sci       Date:  2016-09-07       Impact factor: 5.923
  10 in total

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