Literature DB >> 17125847

Immunopathogenesis of adrenoleukodystrophy: current understanding.

Michelle P Hudspeth1, Gerald V Raymond.   

Abstract

Adrenoleukodystrophy is a neurometabolic disease with a decreased ability to degrade very long chain fatty acids (VLCFA) and significant phenotypic variation. Unlike most neurometabolic diseases, the success of hematopoietic stem cell transplantation (HSCT) is based on acquiring a new immune system rather than enzyme replacement. VLCFA accumulation appears necessary but not sufficient for pathogenesis. Evidence for the involvement of different components of the immune system in the pathogenesis of the cerebral lesions (cellular, cytokines, humoral, and complement) is reviewed, along with both HSCT and non-HSCT immunologic approaches to treatment and future directions.

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Year:  2006        PMID： 17125847     DOI： 10.1016/j.jneuroim.2006.10.009

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  6 in total

1.  Onset of adreno-leukodystrophy after medulloblastoma therapy: causal connection or coincidence?

Authors:  G Deib; A Poretti; A Meoded; K J Cohen; G V Raymond; M Abromowitch; T A G M Huisman
Journal:  JIMD Rep       Date:  2011-09-06

Review 2.  Newborn screening for adrenoleukodystrophy: implications for therapy.

Authors:  Gerald V Raymond; Richard O Jones; Ann B Moser
Journal:  Mol Diagn Ther       Date:  2007       Impact factor: 4.074

3.  Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis.

Authors:  Francisco J Quintana; Mauricio F Farez; Vissia Viglietta; Antonio H Iglesias; Yifat Merbl; Guillermo Izquierdo; Miguel Lucas; Alexandre S Basso; Samia J Khoury; Claudia F Lucchinetti; Irun R Cohen; Howard L Weiner
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-21       Impact factor: 11.205

4.  Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity.

Authors:  Troy C Lund; Paul S Stadem; Angela Panoskaltsis-Mortari; Gerald Raymond; Weston P Miller; Jakub Tolar; Paul J Orchard
Journal:  PLoS One       Date:  2012-02-16       Impact factor: 3.240

5.  Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation.

Authors:  Agatha Schlüter; Juan Sandoval; Stéphane Fourcade; Angel Díaz-Lagares; Montserrat Ruiz; Patrizia Casaccia; Manel Esteller; Aurora Pujol
Journal:  Brain Pathol       Date:  2018-04-10       Impact factor: 6.508

Review 6.  Pre-clinical and Clinical Implications of "Inside-Out" vs. "Outside-In" Paradigms in Multiple Sclerosis Etiopathogenesis.

Authors:  Haley E Titus; Yanan Chen; Joseph R Podojil; Andrew P Robinson; Roumen Balabanov; Brian Popko; Stephen D Miller
Journal:  Front Cell Neurosci       Date:  2020-10-27       Impact factor: 5.505
  6 in total

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