| Literature DB >> 17125248 |
B Wesley Trotter1, Kausik K Nanda, Nathan R Kett, Christopher P Regan, Joseph J Lynch, Gary L Stump, Laszlo Kiss, Jixin Wang, Robert H Spencer, Stefanie A Kane, Rebecca B White, Rena Zhang, Kenneth D Anderson, Nigel J Liverton, Charles J McIntyre, Douglas C Beshore, George D Hartman, Christopher J Dinsmore.
Abstract
Novel 3-cyanoisoquinoline Kv1.5 antagonists have been prepared and evaluated in in vitro and in vivo assays for inhibition of the Kv1.5 potassium channel and its associated cardiac potassium current, IKur. Structural modifications of isoquinolinone lead 1 afforded compounds with excellent potency, selectivity, and oral bioavailability.Entities:
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Year: 2006 PMID： 17125248 DOI： 10.1021/jm060927v
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446