| Literature DB >> 17125247 |
Kazutaka Ikegashira1, Takahiro Oka, Shintaro Hirashima, Satoru Noji, Hiroshi Yamanaka, Yoshinori Hara, Tsuyoshi Adachi, Jun-Ichiro Tsuruha, Satoki Doi, Yasunori Hase, Toru Noguchi, Izuru Ando, Naoki Ogura, Satoru Ikeda, Hiromasa Hashimoto.
Abstract
We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors containing a conformationally constrained tetracyclic scaffold. SAR studies led to the identification of 6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indoles (19 and 20) bearing a basic pendent group with high biochemical and cellular potencies. These compounds displayed a very small shift in cellular potency when the replicon assay was performed in the presence of human serum albumin.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17125247 DOI： 10.1021/jm0610245
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446