Aynur Unalp1, Susan Tonascia, Curtis L Meinert. 1. Center for Clinical Trials, The Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Room W5010, Baltimore Maryland 21205, United States. aunalp@jhsph.edu
Abstract
BACKGROUND: Results from clinical trials are typically disseminated first by presentation at scientific meetings. An important question has to do with the role of presentation in improving the quality of manuscripts submitted to the journals as well as the effect of presentation in speeding, or delaying subsequent publication. The aim of this research is focused on presentation practices of trialists to examine their effect on the timing of publications of clinical trial results. METHODS: Six hundred and one (601) trials published in 1996 and 1997 were identified via MEDLINE using medical subject heading "clinical trials" or the occurrence of the term in the text and by limiting to publication type "clinical trial". Authors of those trials were surveyed to determine prior presentation history for the identified trials. RESULTS: Among the 601 trials identified, complete responses to questionnaires were obtained for 379 (63%) trials. The median time from completion to first submission of the primary results manuscript was 11 months and the median time from completion to publication was 25 months for the 220 trials involving presentation prior to submission for publication. The corresponding median times from completion to first submission and publication for the subset of trials not involving presentation prior to the submission were 8 and 19 months (159 trials), respectively. The adjusted relative hazard for publication for trials involving presentation prior to first submission was 0.55 versus trials not involving presentation prior to first submission (95% confidence interval, 0.44 to 0.69). CONCLUSION: Despite the importance of dissemination of results prior to publication, investigators should carefully weigh a potential gain in quality against a potential for delay in submission of the primary results manuscript by presentation at scientific meetings. The findings of our study suggest that presentation prior to submission may increase time to publication. Inclusion of presentation dates in clinical trial registers should be considered to allow future studies investigating presentation and publication practices.
BACKGROUND: Results from clinical trials are typically disseminated first by presentation at scientific meetings. An important question has to do with the role of presentation in improving the quality of manuscripts submitted to the journals as well as the effect of presentation in speeding, or delaying subsequent publication. The aim of this research is focused on presentation practices of trialists to examine their effect on the timing of publications of clinical trial results. METHODS: Six hundred and one (601) trials published in 1996 and 1997 were identified via MEDLINE using medical subject heading "clinical trials" or the occurrence of the term in the text and by limiting to publication type "clinical trial". Authors of those trials were surveyed to determine prior presentation history for the identified trials. RESULTS: Among the 601 trials identified, complete responses to questionnaires were obtained for 379 (63%) trials. The median time from completion to first submission of the primary results manuscript was 11 months and the median time from completion to publication was 25 months for the 220 trials involving presentation prior to submission for publication. The corresponding median times from completion to first submission and publication for the subset of trials not involving presentation prior to the submission were 8 and 19 months (159 trials), respectively. The adjusted relative hazard for publication for trials involving presentation prior to first submission was 0.55 versus trials not involving presentation prior to first submission (95% confidence interval, 0.44 to 0.69). CONCLUSION: Despite the importance of dissemination of results prior to publication, investigators should carefully weigh a potential gain in quality against a potential for delay in submission of the primary results manuscript by presentation at scientific meetings. The findings of our study suggest that presentation prior to submission may increase time to publication. Inclusion of presentation dates in clinical trial registers should be considered to allow future studies investigating presentation and publication practices.
Authors: Roberta W Scherer; Joerg J Meerpohl; Nadine Pfeifer; Christine Schmucker; Guido Schwarzer; Erik von Elm Journal: Cochrane Database Syst Rev Date: 2018-11-20