| Literature DB >> 17123818 |
Mahama Ouattara1, Sharon Wein, Michèle Calas, Yen Vo Hoang, Henri Vial, Roger Escale.
Abstract
Amidoxime and O-substituted derivatives of the bis-alkylamidine 1,12-bis(N,N'-acetamidinyl)dodecane were synthesized and evaluated as in vitro and in vivo antimalarial prodrugs. The bis-O-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives show relatively potent antimalarial activity after oral administration.Entities:
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Year: 2006 PMID： 17123818 DOI： 10.1016/j.bmcl.2006.11.013
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823