| Literature DB >> 17123807 |
J Grover1, E R Lee, L C Mounkes, C L Stewart, P J Roughley.
Abstract
PRELP is a member of the small leucine-rich repeat proteoglycan family that is abundantly expressed in many cartilages compared to other connective tissues. To study the consequence of PRELP overexpression in tissues where it is normally expressed at low abundance, transgenic mice were generated in which the human PRELP transgene was placed under control of the CMV promoter. A connective tissue phenotype was observed in the skin, where the organization of collagen fibrils in the dermis was perturbed and the thickness of the hypodermal fat layer was diminished.Entities:
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Year: 2006 PMID： 17123807 DOI： 10.1016/j.matbio.2006.10.005
Source DB: PubMed Journal: Matrix Biol ISSN： 0945-053X Impact factor: 11.583