| Literature DB >> 171221 |
M Just, A Buergin-Wolff, G Emoedi, R Hernandez.
Abstract
Trials with live cytomegalovirus (TOWNE 125 strain), which was attenuated by 125 passages exclusively on WI-38 cells, were done in adult volunteers. No virus take occured after oral/nasal application. When 10(3) TCD50 was given intramuscularly an IgG antibody response was detected at four weeks in all of ten volunteers tested by immunofluorescence; an IgM response was found in seven. Only mild local side-effects and relative lymphocytosis were observed. No virus excretion was found. Many questions remain to be answered by further trials before a cytomegalovirus vaccine can be given to adolescent girls.Entities:
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Year: 1975 PMID： 171221 DOI： 10.1007/bf01641052
Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553