| Literature DB >> 17121985 |
Clifford L Wang1, Bruce B Wang, Gábor Bartha, Lauri Li, Namitha Channa, Mark Klinger, Nigel Killeen, Matthias Wabl.
Abstract
Retroviruses can cause tumors when they integrate near a protooncogene or tumor suppressor gene of the host. We infected >2,500 mice with the SL3-3 murine leukemia virus; in 22 resulting tumors, we found provirus integrations nearby or within the gene that contains the mir-17-92 microRNA (miRNA) cistron. Using quantitative real-time PCR, we showed that expression of miRNA was increased in these tumors, indicating that retroviral infection can induce expression of oncogenic miRNAs. Our results demonstrate that retroviral mutagenesis can be a potent tool for miRNA discovery.Entities:
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Year: 2006 PMID： 17121985 PMCID： PMC1693722 DOI： 10.1073/pnas.0609030103
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205