Literature DB >> 17121282

Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones.

Nongluk Sriwilaijaroen1, Mei Liu, Mei-Lin Go, Prapon Wilairat.   

Abstract

Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture.

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Year:  2006        PMID： 17121282

Source DB:  PubMed          Journal:  Southeast Asian J Trop Med Public Health        ISSN： 0125-1562            Impact factor:   0.267


  3 in total

1.  Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria.

Authors:  Marilia Nn Lima; Bruno J Neves; Gustavo C Cassiano; Marcelo N Gomes; Kaira Cp Tomaz; Leticia T Ferreira; Tatyana A Tavella; Juliana Calit; Daniel Y Bargieri; Eugene N Muratov; Fabio Tm Costa; Carolina Horta Andrade
Journal:  Future Med Chem       Date:  2019-09-26       Impact factor: 3.808

2.  O(2)-dependent efficacy of novel piperidine- and piperazine-based chalcones against the human parasite Giardia intestinalis.

Authors:  Vijay Bahadur; Daniela Mastronicola; Hemandra Kumar Tiwari; Yogesh Kumar; Micol Falabella; Leopoldo Paolo Pucillo; Paolo Sarti; Alessandro Giuffrè; Brajendra Kumar Singh
Journal:  Antimicrob Agents Chemother       Date:  2013-11-11       Impact factor: 5.191

3.  In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes.

Authors:  Shweta Sinha; Daniela I Batovska; Bikash Medhi; B D Radotra; Ashish Bhalla; Nadezhda Markova; Rakesh Sehgal
Journal:  Malar J       Date:  2019-12-16       Impact factor: 2.979
  3 in total

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