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Literature DB >> 17120031

Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency.

Carla M Ward¹, Harumi Jyonouchi, Sergei V Kotenko, Sergey V Smirnov, Rakesh Patel, Helen Aguila, George McSherry, Barry Dashefsky, Steven M Holland.

Abstract

We report adjunct treatment of (interferon) IFN-alpha2b (Intron-A) in a patient with complete interferon-gamma receptor R1 (IFNGR1) deficiency suffering from disseminated infection with Mycobacterium avium complex (MAC) resistant to multiple anti-mycobacterial agents. A low dose of IFN-alpha2b (3 x 10(6) units/m(2) three times weekly subcutaneously) successfully attenuated progressive hepatosplenomegaly and abdominal/retroperitoneal/pelvic lymphadenopathy, although the patient continued to be mycobacteremic. This is the first report of a complete IFNGR1 deficiency treated with adjuvant IFN-alpha2b for disseminated MAC infection.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2006 PMID： 17120031 DOI： 10.1007/s00431-006-0339-1

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

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Review 2. Update on phagocytic defects.

Authors: Steven M Holland
Journal: Pediatr Infect Dis J Date: 2003-01 Impact factor: 2.129

3. Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.

Authors: E Jouanguy; F Altare; S Lamhamedi; P Revy; J F Emile; M Newport; M Levin; S Blanche; E Seboun; A Fischer; J L Casanova
Journal: N Engl J Med Date: 1996-12-26 Impact factor: 91.245

4. 561del4 defines a novel small deletion hotspot in the interferon-gamma receptor 1 chain.

Authors: S Rosenzweig; S E Dorman; J Roesler; J Palacios; M Zelazko; S M Holland
Journal: Clin Immunol Date: 2002-01 Impact factor: 3.969

5. Disseminated bacille Calmette-Guérin infection in an infant with a novel deletion in the interferon-gamma receptor gene.

Authors: J A Cunningham; J D Kellner; P J Bridge; C L Trevenen; D R Mcleod; H D Davies
Journal: Int J Tuberc Lung Dis Date: 2000-08 Impact factor: 2.373

Review 6. Listeria monocytogenes and recurrent mycobacterial infections in a child with complete interferon-gamma-receptor (IFNgammaR1) deficiency: mutational analysis and evaluation of therapeutic options.

Authors: J Roesler; B Kofink; J Wendisch; S Heyden; D Paul; W Friedrich; J L Casanova; W Leupold; M Gahr; A Rösen-Wolff
Journal: Exp Hematol Date: 1999-09 Impact factor: 3.084

7. Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency.

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8. Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo.

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9. Persistent Mycobacterium avium infection following nonmyeloablative allogeneic peripheral blood stem cell transplantation for interferon-gamma receptor-1 deficiency.

Authors: Mitchell E Horwitz; Gulbu Uzel; Gilda F Linton; Judi A Miller; Margaret R Brown; Harry L Malech; Steven M Holland
Journal: Blood Date: 2003-06-12 Impact factor: 22.113

Review 10. Interferons, interferon-like cytokines, and their receptors.

Authors: Sidney Pestka; Christopher D Krause; Mark R Walter
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Authors: Daimon P Simmons; David H Canaday; Yi Liu; Qing Li; Alex Huang; W Henry Boom; Clifford V Harding
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3. An overview of cytokines and cytokine antagonists as therapeutic agents.

Authors: Raymond P Donnelly; Howard A Young; Amy S Rosenberg
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4. Hepatoportal venopathy due to disseminated Mycobacterium avium complex infection in a child with IFN-gamma receptor 2 deficiency.

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5. Two patients with complete defects in interferon gamma receptor-dependent signaling.

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Journal: J Clin Immunol Date: 2007-05-21 Impact factor: 8.317

6. Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis.

Authors: Ludovic Desvignes; Andrea J Wolf; Joel D Ernst
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7. Interferon alpha treatment of patients with impaired interferon gamma signaling.

Authors: H I Bax; A F Freeman; L Ding; A P Hsu; B Marciano; E Kristosturyan; T Jancel; C Spalding; J Pechacek; K N Olivier; L A Barnhart; L Boris; C Frein; R J Claypool; V Anderson; C S Zerbe; S M Holland; E P Sampaio
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