| Literature DB >> 17119698 |
Ming Chi Shih1, Marcelo Queiroz Hoexter, Luiz Augusto Franco de Andrade, Rodrigo Affonseca Bressan.
Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson's disease diagnosis (sensitivity and specificity).Entities:
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Year: 2006 PMID： 17119698 DOI： 10.1590/s1516-31802006000300014
Source DB: PubMed Journal: Sao Paulo Med J ISSN： 1516-3180 Impact factor: 1.044