| Literature DB >> 1711914 |
J P Chen1, H M van Praag, E L Gardner.
Abstract
The serotonin-3 (5-HT3) agonist 1-phenylbiguanide (0.1-1.0 mM in perfusate) caused a robust, dose-dependent enhancement of extracellular dopamine content in nucleus accumbens as measured by in vivo microdialysis. This action was antagonized by co-perfusion of the 5-HT3 antagonists zacopride and GR38032F (1 mM in perfusate). Similar effects were observed in 5-HT-denervated rats. These findings suggest that there is a potent modulation of dopamine (DA) release in the nucleus accumbens mediated via 5-HT3 receptors, which appear to be located presynaptically on DA terminals of the mesolimbic DA pathway.Entities:
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Year: 1991 PMID： 1711914 DOI： 10.1016/0006-8993(91)90050-6
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252