OBJECTIVES: To observe the effect of postconditioning on coronary blood flow velocity and endothelial function in acute myocardial infarction (AMI). METHODS: We recruited patients with AMI who underwent primary PCI. The patients were randomized to an ischemic-reperfusion group (IR group) and a postconditioning group. Corrected TIMI frame count (CTFC), Wall motion score index (WMSI), Creatine phosphokinase (CK), CK-MB, malondialdehyde (MDA) were measured. Arterial endothelial function was studied non-invasively by echo Doppler technique. RESULTS: Patients with postconditioning had much faster CTFC. After 8 weeks, the WMSI in Postcond group was significantly larger. There was a significant negative correlation between WMSI and CTFC in IR group and Postcond group(r = - 0.90, p < 0.01; r = - 0.79, p < 0.01). The peaks of CK and CK-MB of Postcond group were much lower than those of the IR group, and MDA-reactive products were significantly lower than those of the IR group after PCI. The endothelium-dependent vasodilatory function was improved in the Postcond group. CONCLUSION:Postconditioning is a simple interventional procedure for salvage of the coronary endothelial function and increasing coronary blood flow velocity.
RCT Entities:
OBJECTIVES: To observe the effect of postconditioning on coronary blood flow velocity and endothelial function in acute myocardial infarction (AMI). METHODS: We recruited patients with AMI who underwent primary PCI. The patients were randomized to an ischemic-reperfusion group (IR group) and a postconditioning group. Corrected TIMI frame count (CTFC), Wall motion score index (WMSI), Creatine phosphokinase (CK), CK-MB, malondialdehyde (MDA) were measured. Arterial endothelial function was studied non-invasively by echo Doppler technique. RESULTS:Patients with postconditioning had much faster CTFC. After 8 weeks, the WMSI in Postcond group was significantly larger. There was a significant negative correlation between WMSI and CTFC in IR group and Postcond group(r = - 0.90, p < 0.01; r = - 0.79, p < 0.01). The peaks of CK and CK-MB of Postcond group were much lower than those of the IR group, and MDA-reactive products were significantly lower than those of the IR group after PCI. The endothelium-dependent vasodilatory function was improved in the Postcond group. CONCLUSION: Postconditioning is a simple interventional procedure for salvage of the coronary endothelial function and increasing coronary blood flow velocity.
Authors: Derek J Hausenloy; William Chilian; Filippo Crea; Sean M Davidson; Peter Ferdinandy; David Garcia-Dorado; Niels van Royen; Rainer Schulz; Gerd Heusch Journal: Cardiovasc Res Date: 2019-06-01 Impact factor: 10.787
Authors: Anna E Mattlage; Ellen N Sutter; Marghuretta D Bland; Swati M Surkar; Jeffrey M Gidday; Jin-Moo Lee; Tamara Hershey; Ling Chen; Catherine E Lang Journal: Exp Brain Res Date: 2019-03-26 Impact factor: 1.972
Authors: Marouane Boukhris; Radhouane Bousselmi; Salvatore Davide Tomasello; Zied Ibn Elhadj; Salvatore Azzarelli; Francesco Marzà; Alfredo R Galassi Journal: J Saudi Heart Assoc Date: 2014-11-20