Literature DB >> 1711876

Evidence for (lipo) oligosaccharides in Borrelia burgdorferi and their serological specificity.

M Cinco1, E Banfi, D Balanzin, C Godeas, E Panfili.   

Abstract

SDS-PAGE and Western immunoblot profiles have been determined for different strains of Borrelia burgdorferi. Major proteins of 60 kDa, 41 kDa corresponding to flagellin, 34-36 kDa and 30-31 kDa corresponding to OspB and OspA respectively, and 18-20 kDa corresponding to 'pC' fractions were detected. A "rough" lipopolysaccharide which we called lipooligosaccharide (LOS) of 8-11 kDa appeared to be present, being detected by specific silver staining, as in crude Borrelia lysates as in proteinase K digested Borrelia strains, quite similar in shape among the different strains examined. The LOS reacted in Western blotting with immune anti-B. burgdorferi rabbit serum and also with sera collected from humans affected by Lyme borreliosis. The LOS did not react with sera positive for syphilis or leptospirosis, and their immunological specificity is discussed.

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Year:  1991        PMID： 1711876     DOI： 10.1111/j.1574-6968.1991.tb04160.x

Source DB:  PubMed          Journal:  FEMS Microbiol Immunol        ISSN： 0920-8534


  8 in total

1.  Identification of an immunoreactive non-proteinaleous component in Borrelia burgdorferi.

Authors:  H Eiffert; H Lotter; K Jarecki-Khan; R Thomssen
Journal:  Med Microbiol Immunol       Date:  1991       Impact factor: 3.402

2.  Synthesis and antigenicity of BBGL-2 glycolipids of Borrelia burgdorferi, the causative agent of Lyme disease.

Authors:  Vince Pozsgay; Joanna Kubler-Kielb; Bruce Coxon; Adriana Marques; John B Robbins; Rachel Schneerson
Journal:  Carbohydr Res       Date:  2011-05-03       Impact factor: 2.104

3.  Borrelia burgdorferi RevA antigen is a surface-exposed outer membrane protein whose expression is regulated in response to environmental temperature and pH.

Authors:  J A Carroll; N El-Hage; J C Miller; K Babb; B Stevenson
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

4.  Relationship between the Borrelia burgdorferi specific immune response and different stages and syndromes in neuroborreliosis.

Authors:  P Oschmann; H J Wellensiek; W Zhong; W Dorndorf; K W Pflughaupt
Journal:  Infection       Date:  1997 Sep-Oct       Impact factor: 3.553

5.  Prevalence of antibodies against Borrelia species in patients with unclassified uveitis in regions in which Lyme disease is endemic and nonendemic.

Authors:  K Kimura; E Isogai; H Isogai; T Nishikawa; T Masuzawa; K Yoshikawa; S Kotake; S Ohno; N Fujii
Journal:  Clin Diagn Lab Immunol       Date:  1995-01

6.  Purification and immunological characterization of a major low-molecular-weight lipoprotein from Borrelia burgdorferi.

Authors:  L I Katona; G Beck; G S Habicht
Journal:  Infect Immun       Date:  1992-12       Impact factor: 3.441

7.  A newly discovered cholesteryl galactoside from Borrelia burgdorferi.

Authors:  Gil Ben-Menachem; Joanna Kubler-Kielb; Bruce Coxon; Alfred Yergey; Rachel Schneerson
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-10       Impact factor: 11.205

8.  Inflammatory mediator release from primary rhesus microglia in response to Borrelia burgdorferi results from the activation of several receptors and pathways.

Authors:  Geetha Parthasarathy; Mario T Philipp
Journal:  J Neuroinflammation       Date:  2015-03-28       Impact factor: 8.322
  8 in total

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