Elizabeth A Miles1, Dinka Rees2, Tapati Banerjee3, Roberta Cazzola4, Sian Lewis5, Richard Wood5, Rachael Oates3, Anna Tallant3, Benvenuto Cestaro4, Parveen Yaqoob5, Klaus W J Wahle2, Philip C Calder3. 1. Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom. Electronic address: eam@soton.ac.uk. 2. The Robert Gordon University and Rowett Research Institute, Aberdeen, United Kingdom. 3. Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom. 4. Department of Preclinical Sciences "LITA Vialba", University of Milan, Milan, Italy. 5. School of Food Biosciences, The University of Reading, Reading, United Kingdom.
Abstract
OBJECTIVE: To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these. METHODS AND RESULTS: Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18-84 years (n=162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for. CONCLUSIONS: Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-1, 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors.
OBJECTIVE: To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these. METHODS AND RESULTS: Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18-84 years (n=162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for. CONCLUSIONS: Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-1, 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors.
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