OBJECTIVES: To determine the safety and efficacy of memantine in treating Age-Associated Memory Impairment (AAMI). METHODS:Sixty adults between 50-79 years of age meeting diagnostic requirements for AAMI were randomly assigned to either memantine (titrated to 20 mg) or a matched placebo and treated for 90 days. An extensive battery of computerized cognitive tests was administered at screening, baseline and, thereafter, at monthly intervals. RESULTS AND CONCLUSION: Study results suggest that the primary cognitive effects of memantine in this population are on attention and information processing speed, rather than on memory. There were no differences in adverse events between memantine and placebo. Copyright (c) 2006 John Wiley & Sons, Ltd.
RCT Entities:
OBJECTIVES: To determine the safety and efficacy of memantine in treating Age-Associated Memory Impairment (AAMI). METHODS: Sixty adults between 50-79 years of age meeting diagnostic requirements for AAMI were randomly assigned to either memantine (titrated to 20 mg) or a matched placebo and treated for 90 days. An extensive battery of computerized cognitive tests was administered at screening, baseline and, thereafter, at monthly intervals. RESULTS AND CONCLUSION: Study results suggest that the primary cognitive effects of memantine in this population are on attention and information processing speed, rather than on memory. There were no differences in adverse events between memantine and placebo. Copyright (c) 2006 John Wiley & Sons, Ltd.
Authors: Peter J Snyder; Susan S Ellenberg; Glenn R Cunningham; Alvin M Matsumoto; Shalender Bhasin; Elizabeth Barrett-Connor; Thomas M Gill; John T Farrar; David Cella; Raymond C Rosen; Susan M Resnick; Ronald S Swerdloff; Jane A Cauley; Denise Cifelli; Laura Fluharty; Marco Pahor; Kristine E Ensrud; Cora E Lewis; Mark E Molitch; Jill P Crandall; Christina Wang; Matthew J Budoff; Nanette K Wenger; Emile R Mohler; Diane E Bild; Nakela L Cook; Tony M Keaveny; David L Kopperdahl; David Lee; Ann V Schwartz; Thomas W Storer; William B Ershler; Cindy N Roy; Leslie J Raffel; Sergei Romashkan; Evan Hadley Journal: Clin Trials Date: 2014-06 Impact factor: 2.486
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Authors: Gregory H Pelton; Oliver L Harper; Matthias H Tabert; Harold A Sackeim; Nikolaos Scarmeas; Steven P Roose; D P Devanand Journal: Int J Geriatr Psychiatry Date: 2008-07 Impact factor: 3.485