| Literature DB >> 17117343 |
Vichai Reutrakul1, Natthinee Anantachoke, Manat Pohmakotr, Thaworn Jaipetch, Samaisukh Sophasan, Chalobon Yoosook, Jittra Kasisit, Chanita Napaswat, Thawatchai Santisuk, Patoomratana Tuchinda.
Abstract
Three new caged xanthones, 7-methoxydesoxymorellin (1), 2-isoprenylforbesione (2) and 8,8a-epoxymorellic acid (3), together with nine known caged xanthones were isolated from the EtOAc extracts of resin and fruits of Garcinia hanburyi. The structures were determined by spectroscopic methods. Most of the isolated compounds showed significant cytotoxicities against a panel of mammalian cancer cell lines. Compound 3, together with the known compounds desoxymorellin, morellic acid, gambogic acid, hanburin, forbesione and dihydroisomorellin, exhibited anti-HIV-1 activity in the reverse transcriptase (RT) assay while the known compounds desoxygambogenin and dihydroisomorellin were found moderately active in the syncytium assay. This work represents the first report on the anti-HIV-1 activities of caged xanthones.Entities:
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Year: 2006 PMID： 17117343 DOI： 10.1055/s-2006-951748
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352