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Literature DB >> 17116671

RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation.

Paloma Anguita-Alonso¹, Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Vittorio Saba, Giorgio Scalise, Milica Sevo, Marina Tuzova, Robin Patel, Naomi Balaban.

Abstract

Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.

Entities: Chemical Disease Species

Mesh：

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Year: 2006 PMID： 17116671 PMCID： PMC1913233 DOI： 10.1128/AAC.00580-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

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Authors: Paloma Anguita-Alonso; Arlen D Hanssen; Douglas R Osmon; Andrej Trampuz; James M Steckelberg; Robin Patel
Journal: Clin Orthop Relat Res Date: 2005-10 Impact factor: 4.176

Review 2. Prosthetic joint infection.

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12 in total

Review 1. Novel approaches to the diagnosis, prevention, and treatment of medical device-associated infections.

Authors: Paschalis Vergidis; Robin Patel
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Journal: Biomed Res Int Date: 2016-01-17 Impact factor: 3.411