Literature DB >> 1711659

Ethanol potentiation of 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cells.

D M Lovinger1.   

Abstract

The effect of acute ethanol (EtOH) exposure on 5-HT3 receptor-mediated ion current was examined in whole-cell patch-clamp recordings from NCB-20 neuroblastoma cells. The physiologic and pharmacologic properties of 5-HT-activated ion current in NCB-20 cells indicated that it was mediated by 5-HT3 receptors. EtOH potentiated 5-HT3 receptor-mediated current in a concentration-dependent manner at concentrations (25-100 mM) which are achieved during EtOH intoxication in vivo.

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Year:  1991        PMID： 1711659     DOI： 10.1016/0304-3940(91)90192-v

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


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