Literature DB >> 17116587

Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins.

Hiroki Hamada1, Kohji Ishihara, Noriyoshi Masuoka, Katsuhiko Mikuni, Nobuyoshi Nakajima.   

Abstract

We investigated the aqueous solubility of paclitaxel using 11 kinds of cyclodextrins (CDs) and the bioactivity of the paclitaxel-CD inclusion complex. 2,6-Dimethyl beta-cyclodextrin was the most effective and its solubility was 2.3 mM in a 0.1 M 2,6-dimethyl beta-cyclodextrin aqueous solution. The inclusion complex of paclitaxel and 2,6-dimethyl beta-cyclodextrin had a 1.23-fold polymerization activity as paclitaxel in a tubulin assay.

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Year:  2006        PMID： 17116587     DOI： 10.1263/jbb.102.369

Source DB:  PubMed          Journal:  J Biosci Bioeng        ISSN： 1347-4421            Impact factor:   2.894


  13 in total

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Authors:  Joshua E Mealy; Christopher B Rodell; Jason A Burdick
Journal:  J Mater Chem B       Date:  2015-09-18       Impact factor: 6.331

Review 2.  Advanced technologies for oral controlled release: cyclodextrins for oral controlled release.

Authors:  Paulo José Salústio; Patrícia Pontes; Claúdia Conduto; Inês Sanches; Catarina Carvalho; João Arrais; Helena M Cabral Marques
Journal:  AAPS PharmSciTech       Date:  2011-09-27       Impact factor: 3.246

Review 3.  A critical review of lipid-based nanoparticles for taxane delivery.

Authors:  Lan Feng; Russell J Mumper
Journal:  Cancer Lett       Date:  2012-07-13       Impact factor: 8.679

4.  Molecular Inclusion Complexes of β-Cyclodextrin Derivatives Enhance Aqueous Solubility and Cellular Internalization of Paclitaxel: Preformulation and In vitro Assessments.

Authors:  Milin Shah; Vatsal Shah; Anasuya Ghosh; Zheng Zhang; Tamara Minko
Journal:  J Pharm Pharmacol (Los Angel)       Date:  2015-01-10

5.  Enhancement of Dissolution of Fenofibrate Using Complexation with Hydroxy Propyl β-Cyclodextrin.

Authors:  Sachin K Jagdale; Mohammad H Dehghan; Nilesh S Paul
Journal:  Turk J Pharm Sci       Date:  2018-12-31

6.  Thermoreversible Pluronic F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies.

Authors:  Shufang Nie; W L Wendy Hsiao; Weisan Pan; Zhijun Yang
Journal:  Int J Nanomedicine       Date:  2011-01-19

7.  The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability.

Authors:  Yiran Ma; Xinyi Zhao; Jian Li; Qi Shen
Journal:  Int J Nanomedicine       Date:  2012-02-02

8.  The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes.

Authors:  Ya-Jing Ye; Yun Wang; Kai-Yan Lou; Yan-Zuo Chen; Rongjun Chen; Feng Gao
Journal:  Int J Nanomedicine       Date:  2015-07-03

9.  Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-β-Cyclodextrin (DEN-HPβCD).

Authors:  Al-Abboodi Shakir Ashwaq; Mothanna Sadiq Al-Qubaisi; Abdullah Rasedee; Ahmad Bustamam Abdul; Yun Hin Taufiq-Yap; Swee Keong Yeap
Journal:  Int J Mol Sci       Date:  2016-10-18       Impact factor: 5.923

Review 10.  Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules.

Authors:  Sonam Choudhary; Lokesh Gupta; Sarita Rani; Kaushalkumar Dave; Umesh Gupta
Journal:  Front Pharmacol       Date:  2017-05-16       Impact factor: 5.810
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