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Literature DB >> 17115943

Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?

Kenji Dohi¹, Kazue Satoh, Tomoya Nakamachi, Sachiko Yofu, Keisuke Hiratsuka, Shunsuke Nakamura, Hirokazu Ohtaki, Toshikazu Yoshikawa, Seiji Shioda, Tohru Aruga.

Abstract

Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.

Entities: Chemical Disease Species

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Year: 2007 PMID： 17115943 DOI： 10.1089/ars.2007.9.281

Source DB: PubMed Journal: Antioxid Redox Signal ISSN： 1523-0864 Impact factor: 8.401

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Cited

9 in total

1. Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.

Authors: Guo-Hua Wang; Zheng-Lin Jiang; Yong-Cai Li; Xia Li; Hong Shi; Yan-Qin Gao; Peter S Vosler; Jun Chen
Journal: J Neurotrauma Date: 2011-09-27 Impact factor: 5.269

2. Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction.

Authors: Kiyoshi Kikuchi; Ko-Ichi Kawahara; Hisaaki Uchikado; Naohisa Miyagi; Terukazu Kuramoto; Tomoya Miyagi; Yoko Morimoto; Takashi Ito; Salunya Tancharoen; Naoki Miura; Kazunori Takenouchi; Yoko Oyama; Binita Shrestha; Fumiyo Matsuda; Yoshihiro Yoshida; Shinihiro Arimura; Kentaro Mera; Ko-Ichi Tada; Narimasa Yoshinaga; Ryuichi Maenosono; Yoshiko Ohno; Teruto Hashiguchi; Ikuro Maruyama; Minoru Shigemori
Journal: Exp Ther Med Date: 2011-06-07 Impact factor: 2.447

3. Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.

Authors: Kenji Dohi; Hirokazu Ohtaki; Tomoya Nakamachi; Sachiko Yofu; Kazue Satoh; Kazuyuki Miyamoto; Dandan Song; Shohko Tsunawaki; Seiji Shioda; Tohru Aruga
Journal: J Neuroinflammation Date: 2010-07-26 Impact factor: 8.322

4. Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons.

Authors: Wen Ji Yuan; Takao Yasuhara; Tetsuro Shingo; Kenichiro Muraoka; Takashi Agari; Masahiro Kameda; Takashi Uozumi; Naoki Tajiri; Takamasa Morimoto; Meng Jing; Tanefumi Baba; Feifei Wang; Hanbai Leung; Toshihiro Matsui; Yasuyuki Miyoshi; Isao Date
Journal: BMC Neurosci Date: 2008-08-01 Impact factor: 3.288

5. Branched-chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein-expressing mice.

Authors: Masaaki Korenaga; Sohji Nishina; Keiko Korenaga; Yasuyuki Tomiyama; Naoko Yoshioka; Yuichi Hara; Yusuke Sasaki; Yasushi Shimonaka; Keisuke Hino
Journal: Liver Int Date: 2014-09-18 Impact factor: 5.828

Review 6. Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration.

Authors: Kenji Dohi; Kazue Satoh; Kazuyuki Miyamoto; Shusuke Momma; Kenichiro Fukuda; Ryo Higuchi; Hirokazu Ohtaki; Williams A Banks
Journal: J Clin Biochem Nutr Date: 2017-06-15 Impact factor: 3.114