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Literature DB >> 1711377

Antibody conjugates with morpholinodoxorubicin and acid-cleavable linkers.

B M Mueller¹, W A Wrasidlo, R A Reisfeld.

Abstract

Antibody-morpholinodoxorubicin conjugates were prepared for targeted immunotherapy of human melanoma. Spacer molecules that differ in hydrolytic stability were employed between the C-13 of the drug and amino residue of lysine on the monoclonal antibody. Antibody-drug conjugates were made with five structurally different morpholinodoxorubicin derivatives including oxime, phenylhydrazone, (sulfonylphenyl)hydrazone, and acylhydrazone moieties. Hydrolytic stability of the antibody conjugates directly correlated with their in vitro cytotoxicity against melanoma cells. Derivatives or conjugates with the greatest hydrolytic stability showed the least cytotoxicity.

Entities: Chemical Disease Gene Species

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Year: 1990 PMID： 1711377 DOI： 10.1021/bc00005a005

Source DB: PubMed Journal: Bioconjug Chem ISSN： 1043-1802 Impact factor: 4.774

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Cited

11 in total

1. Reagents for astatination of biomolecules. 5. Evaluation of hydrazone linkers in (211)At- and (125)I-labeled closo-decaborate(2-) conjugates of Fab' as a means of decreasing kidney retention.

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Journal: Bioconjug Chem Date: 2011-05-05 Impact factor: 4.774

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3. A novel Doxorubicin prodrug with controllable photolysis activation for cancer chemotherapy.

Authors: Stuart Ibsen; Eran Zahavy; Wolf Wrasdilo; Michael Berns; Michael Chan; Sadik Esener
Journal: Pharm Res Date: 2010-07-02 Impact factor: 4.200

4. A Pictet-Spengler ligation for protein chemical modification.

Authors: Paresh Agarwal; Joep van der Weijden; Ellen M Sletten; David Rabuka; Carolyn R Bertozzi
Journal: Proc Natl Acad Sci U S A Date: 2012-12-13 Impact factor: 11.205

5. Preparation and in vivo evaluation of radioiodinated closo-decaborate(2-) derivatives to identify structural components that provide low retention in tissues.

Authors: D Scott Wilbur; Ming-Kuan Chyan; Donald K Hamlin; Matthew A Perry
Journal: Nucl Med Biol Date: 2010-02 Impact factor: 2.408

Antibody conjugates with morpholinodoxorubicin and acid-cleavable linkers.

1. Reagents for astatination of biomolecules. 5. Evaluation of hydrazone linkers in (211)At- and (125)I-labeled closo-decaborate(2-) conjugates of Fab' as a means of decreasing kidney retention.

Review 2. Alternate routes for drug delivery to the cell interior: pathways to the Golgi apparatus and endoplasmic reticulum.

3. A novel Doxorubicin prodrug with controllable photolysis activation for cancer chemotherapy.

4. A Pictet-Spengler ligation for protein chemical modification.

5. Preparation and in vivo evaluation of radioiodinated closo-decaborate(2-) derivatives to identify structural components that provide low retention in tissues.

6. Localized in vivo activation of a photoactivatable doxorubicin prodrug in deep tumor tissue.

Review 7. Nature as a source of inspiration for cationic lipid synthesis.

Review 8. Use of antibodies and immunoconjugates for the therapy of more accessible cancers.

9. Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus.

Review 10. Stepping forward in antibody-drug conjugate development.