| Literature DB >> 17113582 |
Alena Vaculová1, Jirina Hofmanová, Karel Soucek, Alois Kozubík.
Abstract
Epithelial cells can be manipulated to undergo apoptosis depending on the balance between pro-survival and apoptotic signals. We showed that TRAIL-induced apoptosis may be differentially regulated by inhibitors of MEK ERK (U0126) or PI3K/Akt (LY294002) pathway in TRAIL-sensitive (HT-29) and TRAIL-resistant (SW620) human epithelial colon cancer cells. U0126 or LY294002 significantly enhanced TRAIL-induced apoptosis in HT-29 cells, but not in SW620 cells. We report a different regulation of the level of an anti-apoptotic Mcl-1 protein under MEK/ERK or PI3K/Akt pathway inhibition and suggest the mechanisms involved. A special attention was paid to the role of the ERK1/2, Akt, and glycogen synthase kinase 3beta.Entities:
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Year: 2006 PMID： 17113582 DOI： 10.1016/j.febslet.2006.11.004
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124