| Literature DB >> 17113292 |
Glenn Noronha1, Kathy Barrett, Antonio Boccia, Tessa Brodhag, Jianguo Cao, Chun P Chow, Elena Dneprovskaia, John Doukas, Richard Fine, Xianchang Gong, Colleen Gritzen, Hong Gu, Ehab Hanna, John D Hood, Steven Hu, Xinshan Kang, Jann Key, Boris Klebansky, Ahmed Kousba, Ge Li, Dan Lohse, Chi Ching Mak, Andrew McPherson, Moorthy S S Palanki, Ved P Pathak, Joel Renick, Feng Shi, Richard Soll, Ute Splittgerber, Silva Stoughton, Suhan Tang, Shiyin Yee, Binqi Zeng, Ningning Zhao, Hong Zhu.
Abstract
We describe the identification of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine (3), a potent, orally active Src inhibitor with desirable PK properties, demonstrated activity in human tumor cell lines and in animal models of tumor growth.Entities:
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Year: 2006 PMID： 17113292 DOI： 10.1016/j.bmcl.2006.11.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823