| Literature DB >> 17113258 |
So Tando1, Kyoko Itoh, Takeshi Yaoi, Jun Ikeda, Yasuhiro Fujiwara, Shinji Fushiki.
Abstract
Bisphenol A (BPA), known as an environmental endocrine disrupter, is widely used in industry and dentistry. We investigated the effects of fetal and neonatal exposure to bisphenol A (BPA) on the brain development of mice. The density of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons in substantia nigra was significantly decreased in BPA-exposed female mice (3 microg/g powder food), but not in the male mice, as compared with that of the control mice. The densities of calbindin D-28 K-, calretinin- and parvalbumin-IR neurons in the cerebral cortex were not different between BPA-exposed and the control mice. The present study indicates that chronic exposure of BPA during prenatal and neonatal periods causes a decrease of TH-positive neurons in substantia nigra only in female mice brain.Entities:
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Year: 2006 PMID： 17113258 DOI： 10.1016/j.braindev.2006.10.003
Source DB: PubMed Journal: Brain Dev ISSN： 0387-7604 Impact factor: 1.961