| Literature DB >> 17113224 |
Maureen van den Donk1, Marleen H P W Visker, Jan L Harryvan, Frans J Kok, Ellen Kampman.
Abstract
Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.Entities:
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Year: 2006 PMID： 17113224 DOI： 10.1016/j.canlet.2006.10.002
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679