Literature DB >> 17113198

Absence of angiogenic genes modification in Italian ALS patients.

Roberto Del Bo1, Marina Scarlato, Serena Ghezzi, Filippo Martinelli-Boneschi, Stefania Corti, Federica Locatelli, Domenico Santoro, Alessandro Prelle, Chiara Briani, Martina Nardini, Gabriele Siciliano, Michelangelo Mancuso, Luigi Murri, Nereo Bresolin, Giacomo Pietro Comi.   

Abstract

To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic determinants in the susceptibility to sporadic ALS in Italian patients. VEGF genotype and haplotype analysis revealed no association between any variants and the risk of ALS. Regarding ANG gene, no mutation was detected and the rs11701 polymorphism, previously described as associated with ALS, was not differently distributed between patients and controls. Overall, our data argue against the hypothesis of both genes as risk factors for motoneuron neurodegeneration, at least in an Italian population.

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Year:  2006        PMID： 17113198     DOI： 10.1016/j.neurobiolaging.2006.10.008

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  12 in total

Review 1.  Gene and protein therapies utilizing VEGF for ALS.

Authors:  Orion P Keifer; Deirdre M O'Connor; Nicholas M Boulis
Journal:  Pharmacol Ther       Date:  2013-10-29       Impact factor: 12.310

2.  No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort.

Authors:  Roberto Del Bo; Stefania Corti; Domenico Santoro; Isabella Ghione; Chiara Fenoglio; Serena Ghezzi; Michela Ranieri; Daniela Galimberti; Michelangelo Mancuso; Gabriele Siciliano; Chiara Briani; Luigi Murri; Elio Scarpini; Jennifer C Schymick; Bryan J Traynor; Nereo Bresolin; Giacomo P Comi
Journal:  Neurobiol Aging       Date:  2009-07-25       Impact factor: 4.673

Review 3.  Lack of association between the Angiogenin (ANG) rs11701 polymorphism and amyotrophic lateral sclerosis risk: a meta-analysis.

Authors:  Li-Shou Pan; Xin-Bo Deng; Zheng Wang; Hui-Lin Leng; Xue-Peng Zhu; Dan Ding
Journal:  Neurol Sci       Date:  2016-01-11       Impact factor: 3.307

4.  Association between the Angiogenin (ANG) K17I variant and amyotrophic lateral sclerosis risk in Caucasian: a meta-analysis.

Authors:  Lishou Pan; Xinbo Deng; Dan Ding; Huilin Leng; Xuepeng Zhu; Zheng Wang
Journal:  Neurol Sci       Date:  2015-08-09       Impact factor: 3.307

Review 5.  Targeting angiogenin in therapy of amyotropic lateral sclerosis.

Authors:  Hiroko Kishikawa; David Wu; Guo-fu Hu
Journal:  Expert Opin Ther Targets       Date:  2008-10       Impact factor: 6.902

6.  Extensive genetics of ALS: a population-based study in Italy.

Authors:  Adriano Chiò; Andrea Calvo; Letizia Mazzini; Roberto Cantello; Gabriele Mora; Cristina Moglia; Lucia Corrado; Sandra D'Alfonso; Elisa Majounie; Alan Renton; Fabrizio Pisano; Irene Ossola; Maura Brunetti; Bryan J Traynor; Gabriella Restagno
Journal:  Neurology       Date:  2012-10-24       Impact factor: 9.910

7.  Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis.

Authors:  Cinzia Gellera; Claudia Colombrita; Nicola Ticozzi; Barbara Castellotti; Cinzia Bragato; Antonia Ratti; Franco Taroni; Vincenzo Silani
Journal:  Neurogenetics       Date:  2007-12-18       Impact factor: 2.660

Review 8.  Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis.

Authors:  Michael A van Es; Helenius J Schelhaas; Paul W J van Vught; Nicola Ticozzi; Peter M Andersen; Ewout J N Groen; Claudia Schulte; Hylke M Blauw; Max Koppers; Frank P Diekstra; Katsumi Fumoto; Ashley Lyn LeClerc; Pamela Keagle; Bastiaan R Bloem; Hans Scheffer; Bart F L van Nuenen; Marka van Blitterswijk; Wouter van Rheenen; Anne-Marie Wills; Patrick P Lowe; Guo-fu Hu; Wenhao Yu; Hiroko Kishikawa; David Wu; Rebecca D Folkerth; Claudio Mariani; Stefano Goldwurm; Gianni Pezzoli; Philip Van Damme; Robin Lemmens; Caroline Dahlberg; Anna Birve; Rubén Fernández-Santiago; Stefan Waibel; Christine Klein; Markus Weber; Anneke J van der Kooi; Marianne de Visser; Dagmar Verbaan; Jacobus J van Hilten; Peter Heutink; Eric A M Hennekam; Edwin Cuppen; Daniela Berg; Robert H Brown; Vincenzo Silani; Thomas Gasser; Albert C Ludolph; Wim Robberecht; Roel A Ophoff; Jan H Veldink; R Jeroen Pasterkamp; Paul I W de Bakker; John E Landers; Bart P van de Warrenburg; Leonard H van den Berg
Journal:  Ann Neurol       Date:  2011-12       Impact factor: 10.422

9.  Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis.

Authors:  Rubén Fernández-Santiago; Sabine Hoenig; Peter Lichtner; Anne-Dorte Sperfeld; Manu Sharma; Daniela Berg; Oliver Weichenrieder; Thomas Illig; Katharina Eger; Thomas Meyer; Johanna Anneser; Christoph Münch; Stephan Zierz; Thomas Gasser; Albert Ludolph
Journal:  J Neurol       Date:  2009-04-12       Impact factor: 4.849

10.  Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutation.

Authors:  J Kirby; J R Highley; L Cox; E F Goodall; C Hewitt; J A Hartley; H C Hollinger; M Fox; P G Ince; C J McDermott; P J Shaw
Journal:  Neuropathol Appl Neurobiol       Date:  2013-08       Impact factor: 8.090
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