Literature DB >> 17112639

Effect of substituents on diarylmethanes for antitubercular activity.

Gautam Panda1, Maloy Kumar Parai, Sajal Kumar Das, Manish Sinha, Vinita Chaturvedi, Anil K Srivastava, Y S Manju, Anil N Gaikwad, Sudhir Sinha.   

Abstract

Aminoalkyl derivatives of diarylmethanes were prepared using Grignard, Friedel-Crafts arylation and aminohydrochloride chain formation reactions. These series of compounds were evaluated against Mycobacterium tuberculosis H(37)R(v) and showed the activity in the range of 6.25-25 microg/mL. Effect of heteroaryl, anthracenyl and phenanthrene groups on diarylmethane pharmacophores for antitubercular activity is described.

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Year:  2006        PMID： 17112639     DOI： 10.1016/j.ejmech.2006.09.020

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  9 in total

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2.  Selective synthesis of either enantiomer of an anti-breast cancer agent via a common enantioenriched intermediate.

Authors:  Aaron George Johnson; Marissa M Tranquilli; Michael R Harris; Elizabeth R Jarvo
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

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Authors:  Umashankar Das; Swagatika Das; Brian Bandy; James P Stables; Jonathan R Dimmock
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5.  Antiplasmodial activity of [(aryl)arylsulfanylmethyl]Pyridine.

Authors:  Sanjay Kumar; Sajal Kumar Das; Sumanta Dey; Pallab Maity; Mithu Guha; Vinay Choubey; Gautam Panda; Uday Bandyopadhyay
Journal:  Antimicrob Agents Chemother       Date:  2007-11-19       Impact factor: 5.191

6.  Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Authors:  Anup Aggarwal; Maloy K Parai; Nishant Shetty; Deeann Wallis; Lisa Woolhiser; Courtney Hastings; Noton K Dutta; Stacy Galaviz; Ramesh C Dhakal; Rupesh Shrestha; Shoko Wakabayashi; Chris Walpole; David Matthews; David Floyd; Paul Scullion; Jennifer Riley; Ola Epemolu; Suzanne Norval; Thomas Snavely; Gregory T Robertson; Eric J Rubin; Thomas R Ioerger; Frik A Sirgel; Ruben van der Merwe; Paul D van Helden; Peter Keller; Erik C Böttger; Petros C Karakousis; Anne J Lenaerts; James C Sacchettini
Journal:  Cell       Date:  2017-06-29       Impact factor: 41.582

7.  Fe(OTf)3-catalysed Friedel-Crafts reaction of benzenoid arenes with α,β-unsaturated carbonyl compounds: easy access to 1,1-diarylalkanes.

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8.  A selective removal of the secondary hydroxy group from ortho-dithioacetal-substituted diarylmethanols.

Authors:  Anna Czarnecka; Emilia Kowalska; Agnieszka Bodzioch; Joanna Skalik; Marek Koprowski; Krzysztof Owsianik; Piotr Bałczewski
Journal:  Beilstein J Org Chem       Date:  2018-05-29       Impact factor: 2.883

9.  Metal- and solvent-free synthesis of aniline- and phenol-based triarylmethanes via Brönsted acidic ionic liquid catalyzed Friedel-Crafts reaction.

Authors:  Nipaphorn Ponpao; Warapong Senapak; Rungnapha Saeeng; Jaray Jaratjaroonphong; Uthaiwan Sirion
Journal:  RSC Adv       Date:  2021-06-30       Impact factor: 4.036
  9 in total

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