| Literature DB >> 17112609 |
Antonio Abbate, Celina Morales, Maria De Falco, Valentina Fedele, Giuseppe G L Biondi Zoccai, Daniele Santini, Jimena Palleiro, Fortunata Vasaturo, Susanna Scarpa, Giovanna Liuzzo, Anna Severino, Feliciano Baldi, Filippo Crea, Luigi M Biasucci, George W Vetrovec, Ricardo J Gelpi, Alfonso Baldi.
Abstract
Apoptosis is a pathologic feature of cardiomyocytes in acute myocardial infarction (AMI) and heart failure. The temporal course of apoptosis in the peri-infarct area in the weeks following an AMI is still uncompletely defined. In order to study the time course of apoptosis after AMI, 16 rabbits underwent left coronary artery ligation and were sacrificed at 16, 26, 35, and 56 days after surgery. Increased apoptotic rate (AR) was observed at in the peri-infarct region than in remote myocardium (5.4% [2.5-9.6] vs 0.4% [0.1-0.9], respectively, P<0.001) and than in sham-operated cases (0.01% [0-0.02], P<0.001). A gradual decrease of AR in the peri-infarct region was observed over time with a 90% reduction at 8 weeks after coronary ligation.Entities:
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Year: 2006 PMID： 17112609 DOI： 10.1016/j.ijcard.2006.08.077
Source DB: PubMed Journal: Int J Cardiol ISSN： 0167-5273 Impact factor: 4.164