| Literature DB >> 17112530 |
Jack W Kent1, Michael C Mahaney, Anthony G Comuzzie, Harald H H Göring, Laura Almasy, Thomas D Dyer, Shelley A Cole, Jean W MacCluer, John Blangero.
Abstract
Circulating soluble intercellular adhesion molecule-1 (sICAM-1) is a biochemical marker of inflammation. We performed variance-components-based quantitative genetic analyses in SOLAR of sICAM-1 in 1170 individuals from Mexican American families in the San Antonio Family Heart Study. The trait is heritable (h(2)=0.50+/-0.06, P<10(-6)). Multipoint linkage analysis using a approximately 10-cM microsatellite map revealed a region on Chromosome 19p near marker D19S586 showing strong evidence of linkage for sICAM-1 (empirically adjusted univariate-equivalent LOD=4.95), coincident with the structural gene ICAM1. This region has been identified previously as a QTL for inflammatory, autoimmune, and metabolic syndrome traits. There is significant evidence (P=0.0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait.Entities:
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Year: 2006 PMID： 17112530 PMCID： PMC2719976 DOI： 10.1016/j.atherosclerosis.2006.10.005
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162