BACKGROUND: To determine whether there is an ecological association between antibiotic use and chlamydia prevalence. METHODS: A systematic review was undertaken of international studies on chlamydia prevalence among women aged 15-25 years published between 2000 and 2005. Preference was given to studies using nucleic acid testing and representative population-based sampling methods. Data were obtained on per capita antibiotic consumption according to the defined daily dose. RESULTS: For the 12 countries for which both antibiotic consumption and relevant prevalence data for chlamydia were available, a non-significant negative correlation was found between total antibiotic consumption per capita and chlamydia prevalence among younger women according to country (r(s) = -0.242, P = 0.449). When an outlier (from the Netherlands) was excluded, the correlation was significant (r(s) = -0.615, P = 0.044). Combined use of tetracyclines and macrolides was also associated with lower chlamydia prevalence (r(s) = -0.697, P = 0.017). CONCLUSIONS: It is possible that antibiotics used for other reasons may have unexpectedly reduced the prevalence of chlamydia.
BACKGROUND: To determine whether there is an ecological association between antibiotic use and chlamydia prevalence. METHODS: A systematic review was undertaken of international studies on chlamydia prevalence among women aged 15-25 years published between 2000 and 2005. Preference was given to studies using nucleic acid testing and representative population-based sampling methods. Data were obtained on per capita antibiotic consumption according to the defined daily dose. RESULTS: For the 12 countries for which both antibiotic consumption and relevant prevalence data for chlamydia were available, a non-significant negative correlation was found between total antibiotic consumption per capita and chlamydia prevalence among younger women according to country (r(s) = -0.242, P = 0.449). When an outlier (from the Netherlands) was excluded, the correlation was significant (r(s) = -0.615, P = 0.044). Combined use of tetracyclines and macrolides was also associated with lower chlamydia prevalence (r(s) = -0.697, P = 0.017). CONCLUSIONS: It is possible that antibiotics used for other reasons may have unexpectedly reduced the prevalence of chlamydia.
Authors: Nicole H T M Dukers-Muijrers; Genevieve A F S van Liere; Petra F G Wolffs; Casper Den Heijer; Marita I L S Werner; Christian J P A Hoebe Journal: Antimicrob Agents Chemother Date: 2014-10-13 Impact factor: 5.191
Authors: Jennifer Walker; Christopher K Fairley; Catriona S Bradshaw; Sepehr N Tabrizi; Marcus Y Chen; Jimmy Twin; Nicole Taylor; Basil Donovan; John K Kaldor; Kathleen McNamee; Eve Urban; Sandra Walker; Marian Currie; Hudson Birden; Francis Bowden; Jane Gunn; Marie Pirotta; Lyle Gurrin; Veerakathy Harindra; Suzanne Garland; Jane S Hocking Journal: BMC Infect Dis Date: 2011-02-01 Impact factor: 3.090
Authors: Lenka A Vodstrcil; Christopher K Fairley; Glenda Fehler; David Leslie; Jennifer Walker; Catriona S Bradshaw; Jane S Hocking Journal: BMC Infect Dis Date: 2011-06-05 Impact factor: 3.090
Authors: Jennifer Walker; Sepehr N Tabrizi; Christopher K Fairley; Marcus Y Chen; Catriona S Bradshaw; Jimmy Twin; Nicole Taylor; Basil Donovan; John M Kaldor; Kathleen McNamee; Eve Urban; Sandra Walker; Marian Currie; Hudson Birden; Francis Bowden; Jane Gunn; Marie Pirotta; Lyle Gurrin; Veerakathy Harindra; Suzanne M Garland; Jane S Hocking Journal: PLoS One Date: 2012-05-25 Impact factor: 3.240
Authors: Naomi C A Juliana; Abdulla Mbaruk Omar; Jolein Pleijster; Fahad Aftab; Nina B Uijldert; Said M Ali; Sander Ouburg; Sunil Sazawal; Servaas A Morré; Saikat Deb; Elena Ambrosino Journal: Microorganisms Date: 2021-05-30