Literature DB >> 17111471

Anticancer effects of Chinese herbal medicine, science or myth?

Wen-jing Ruan1, Mao-de Lai, Jian-guang Zhou.   

Abstract

Currently there is considerable interest among oncologists to find anticancer drugs in Chinese herbal medicine (CHM). In the past, clinical data showed that some herbs possessed anticancer properties, but western scientists have doubted the scientific validity of CHM due to the lack of scientific evidence from their perspective. Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of CHM. Experiments showed that CHM played its anticancer role by inducing apoptosis and differentiation, enhancing the immune system, inhibiting angiogenesis, reversing multidrug resistance (MDR), etc. Clinical trials demonstrated that CHM could improve survival, increase tumor response, improve quality of life, or reduce chemotherapy toxicity, although much remained to be determined regarding the objective effects of CHM in human in the context of clinical trials. Interestingly, both laboratory experiments and clinical trials have demonstrated that when combined with chemotherapy, CHM could raise the efficacy level and lower toxic reactions. These facts raised the feasibility of the combination of herbal medicines and chemotherapy, although much remained to be investigated in this area.

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Year:  2006        PMID: 17111471      PMCID: PMC1661669          DOI: 10.1631/jzus.2006.B1006

Source DB:  PubMed          Journal:  J Zhejiang Univ Sci B        ISSN: 1673-1581            Impact factor:   3.066


  38 in total

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4.  Growth inhibition and apoptosis of gastric cancer cell lines by Anemarrhena asphodeloides Bunge.

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Journal:  J Gastroenterol       Date:  2001-02       Impact factor: 7.527

5.  Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract.

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6.  In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins.

Authors:  G Q Chen; J Zhu; X G Shi; J H Ni; H J Zhong; G Y Si; X L Jin; W Tang; X S Li; S M Xong; Z X Shen; G L Sun; J Ma; P Zhang; T D Zhang; C Gazin; T Naoe; S J Chen; Z Y Wang; Z Chen
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Authors:  William K Oh; Philip W Kantoff; Vivian Weinberg; Graham Jones; Brian I Rini; Mika K Derynck; Robert Bok; Matthew R Smith; Glenn J Bubley; Robert T Rosen; Robert S DiPaola; Eric J Small
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Journal:  Anticancer Res       Date:  2004 Mar-Apr       Impact factor: 2.480

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Authors:  Yun-Yi Cha; Eun-Ok Lee; Hyo-Jeong Lee; Young-Doo Park; Seong-Gyu Ko; Dong-Hee Kim; Hyung-Min Kim; In-Cheol Kang; Sung-Hoon Kim
Journal:  Clin Chim Acta       Date:  2004-10       Impact factor: 3.786

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  22 in total

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Authors:  Charles H Leseberg; Melvin R Duvall
Journal:  J Mol Evol       Date:  2009-09-24       Impact factor: 2.395

2.  Phyllanthus emblica Linn. fruit extract potentiates the anticancer efficacy of mitomycin C and cisplatin and reduces their genotoxicity to normal cells in vitro.

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Journal:  J Zhejiang Univ Sci B       Date:  2017 Dec.       Impact factor: 3.066

3.  Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo.

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4.  Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides.

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Journal:  Oncol Lett       Date:  2017-01-17       Impact factor: 2.967

5.  Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.

Authors:  Siti Susanti; Hironori Iwasaki; Yukiyoshi Itokazu; Mariko Nago; Naoyuki Taira; Seikoh Saitoh; Hirosuke Oku
Journal:  J Nat Med       Date:  2012-02-16       Impact factor: 2.343

6.  Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice.

Authors:  Qing-E Tian; Huan-De Li; Miao Yan; Hua-Lin Cai; Qin-You Tan; Wen-Yuan Zhang
Journal:  World J Gastroenterol       Date:  2012-12-21       Impact factor: 5.742

7.  An elderly patient with advanced lung cancer achieved long-term survival using Chinese medicine: An alternative treatment strategy for cancer patients aged 80 or older without a tissue confirmed diagnosis.

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8.  A Chinese herbal Formula, Chang-Wei-Qin, Synergistically Enhances Antitumor Effect of Oxaliplatin.

Authors:  Yong Zhang; Qiang Zhang; Zhongze Fan; Jue Sun; Xulin Liu; Lingling Cheng; Ao Li; Jianhua Xu
Journal:  Pathol Oncol Res       Date:  2014-08-08       Impact factor: 3.201

9.  Selective fraction of Atractylodes lancea (Thunb.) DC. and its growth inhibitory effect on human gastric cancer cells.

Authors:  Ming Zhao; Qingqing Wang; Zhen Ouyang; Bangxing Han; Wenbing Wang; Yuan Wei; Yan Wu; Bing Yang
Journal:  Cytotechnology       Date:  2013-04-07       Impact factor: 2.058

10.  Use of chinese herb medicine in cancer patients: a survey in southwestern china.

Authors:  Tai-Guo Liu; Shao-Quan Xiong; Yan Yan; Hong Zhu; Cheng Yi
Journal:  Evid Based Complement Alternat Med       Date:  2012-09-11       Impact factor: 2.629

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