Literature DB >> 171111

Thymus transplantation. Reconstitution of cellular immunity in a four-year-old patient with T-cell deficiency.

L Businco, E Rezza, G Giunchi, F Aiuti.   

Abstract

The case is reported of a 4-year-old girl affected with recurrent infections; anaemia, thrombocytopenia, haemorrhages and hepatosplenomegaly. Immunological investigations revealed a defect in cellular immunity related to the thymus-dependent system, hypergammaglobulinaemia (especially of class IgE), and very high titres of antibodies against Epstein-Barr virus (EBV). After foetal thymus transplantation, correction of the immunological defect and significant clinical improvement were noted, as well as a decrease of IgE and EBV antibody titres.

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Year:  1975        PMID： 171111      PMCID： PMC1538249     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  27 in total

1.  Elevated antibody titers to Epstein-Barr virus in Hodgkin's disease.

Authors:  P H Levine; D V Ablashi; C W Berard; P P Carbone; D E Waggoner; L Malan
Journal:  Cancer       Date:  1971-02       Impact factor: 6.860

2.  Hypergammaglobulinaemia, antibody deficiency, autoimmune haemolytic anaemia, and nephritis in an infant with a familial lymphopenic immune defect.

Authors:  J Schaller; S D Davis; Y C Ching; D Lagunoff; C P Williams; R J Wedgwood
Journal:  Lancet       Date:  1966-10-15       Impact factor: 79.321

3.  Target cell of thymic hormone.

Authors:  J F Bach
Journal:  Lancet       Date:  1973-06-09       Impact factor: 79.321

4.  Familial lymphopenia with T lymphocyte defect.

Authors:  E Rezza; F Aiuti; L Businco; M A Castello
Journal:  J Pediatr       Date:  1974-02       Impact factor: 4.406

5.  Function and distribution pattern of human T lymphocytes. I. Production of anti-T lymphocyte specific sera as estimated by cytotoxicity and elimination of function of lymphocytes.

Authors:  F Aiuti; H Wigzell
Journal:  Clin Exp Immunol       Date:  1973-02       Impact factor: 4.330

6.  DiGeorge syndrome associated with combined immunodeficiency. Dissociation of phytohemagglutinin and mixed leukocyte culture responses.

Authors:  R A Gatti; J J Gershanik; A H Levkoff; W Wertelecki; R A Good
Journal:  J Pediatr       Date:  1972-11       Impact factor: 4.406

7.  Foetal thymic transplant in a case of Digeorge's syndrome.

Authors:  W W Cleveland; B J Fogel; W T Brown; H E Kay
Journal:  Lancet       Date:  1968-12-07       Impact factor: 79.321

8.  Implantation of a foetal thymus, restoring immunological competence in a patient with thymic aplasia (Digeorge's syndrome).

Authors:  C S August; F S Rosen; R M Filler; C A Janeway; B Markowski; H E Kay
Journal:  Lancet       Date:  1968-12-07       Impact factor: 79.321

9.  Thymus transplantation. Permanent reconstitution of cellular immunity in a patient with sex-linked combined immunodeficiency.

Authors:  A J Ammann; D W Wara; S Salmon; H Perkins
Journal:  N Engl J Med       Date:  1973-07-05       Impact factor: 91.245

10.  Thymic alymphoplasia, lymphoma, and dys-gamma-globulinemia, hyper-gamma A-, normo-gamma M-, hypo-gamma G, a-gamma D-, and gamma E-globulinemia, plasmacytosis, normal delayed hypersensitivity, severe allergic reactions, and Coombs' positive anemia.

Authors:  A S Goldman; M E Haggard; J McFadden; S E Ritzmann; E W Houston; R L Bratcher; K G Weiss; E M Box; J W Szekrenyes
Journal:  Pediatrics       Date:  1967-03       Impact factor: 7.124
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  1 in total

1.  Management of Inborn Errors of Immunity in the Genomic Era.

Authors:  Doğa Damla Demir; Kosar Asnaashari; Nima Rezaei; Ahmet Özen
Journal:  Turk Arch Pediatr       Date:  2022-03
  1 in total

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