| Literature DB >> 17109966 |
Annemarie E Brouwer1, Asna A Siddiqui, Maartje I Kester, Kim C E Sigaloff, Adul Rajanuwong, Saran Wannapasni, Wirongrong Chierakul, Thomas S Harrison.
Abstract
The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-gamma, TNF-alpha, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease.Entities:
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Year: 2006 PMID： 17109966 DOI： 10.1016/j.jinf.2006.10.002
Source DB: PubMed Journal: J Infect ISSN： 0163-4453 Impact factor: 6.072