| Literature DB >> 17109828 |
Wendy M Brooks1, Patrick J Lynch, Catherine C Ingle, Alexander Hatton, Piers C Emson, Richard L M Faull, Mike P Starkey.
Abstract
The successfully functioning brain is a heavy user of metabolic energy. Alzheimer's disease, in which cognitive faculties decline, may be due, at least in part, to metabolic insufficiency. Using microarray analysis and quantitative RT-PCR, the expression of mRNA transcripts involved in glucose metabolism was investigated in Alzheimer's diseased post-mortem human hippocampal samples. Of the 51 members of the glycolytic, tricarboxylic acid cycle, oxidative phosphorylation, and associated pathways investigated by qPCR, 15 were confirmed to be statistically significantly (p<0.05) down-regulated in Alzheimer's disease. This finding suggests that reductions in the levels of transcripts encoded by genes that participate in energy metabolism may be involved in Alzheimer's disease.Entities:
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Year: 2006 PMID： 17109828 DOI： 10.1016/j.brainres.2006.09.106
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252