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Literature DB >> 17109510

Current concepts and controversies in the treatment of alcoholic hepatitis.

Abstract

The treatment of alcoholic hepatitis remains one of the most debated topics in medicine and a field of continued research. In this review, we discuss the evolution of scoring systems, including the recent development of the Glasgow alcoholic hepatitis score, role of liver biopsy and current treatment interventions. Studies of treatment interventions with glucocorticoids, pentoxifylline, infliximab, s-adenosyl-methionine, and colchicine are reviewed with discussion on quality. Glucocorticoids currently remain the mainstay of treatment for severe alcoholic hepatitis.

Entities: Chemical Disease

Mesh：

Substances：
Glucocorticoids

Year: 2006 PMID： 17109510 PMCID： PMC4087332 DOI： 10.3748/wjg.v12.i43.6909

Source DB: PubMed Journal: World J Gastroenterol ISSN： 1007-9327 Impact factor: 5.742

124 in total

1. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH.

Authors: Philippe Mathurin; Charles L Mendenhall; Robert L Carithers; Marie-Jose Ramond; Willis C Maddrey; Peter Garstide; Bernard Rueff; Sylvie Naveau; Jean-Claude Chaput; Thierry Poynard
Journal: J Hepatol Date: 2002-04 Impact factor: 25.083

2. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.

Authors: P E Lipsky; D M van der Heijde; E W St Clair; D E Furst; F C Breedveld; J R Kalden; J S Smolen; M Weisman; P Emery; M Feldmann; G R Harriman; R N Maini
Journal: N Engl J Med Date: 2000-11-30 Impact factor: 91.245

3. Burden of liver disease in the United States: summary of a workshop.

Authors: W Ray Kim; Robert S Brown; Norah A Terrault; Hashem El-Serag
Journal: Hepatology Date: 2002-07 Impact factor: 17.425

Review 4. Meta-analysis of propylthiouracil for alcoholic liver disease--a Cochrane Hepato-Biliary Group Review.

Authors: A Rambaldi; C Gluud
Journal: Liver Date: 2001-12

Review 5. S-adenosyl-L-methionine for alcoholic liver diseases.

Authors: A Rambaldi; C Gluud
Journal: Cochrane Database Syst Rev Date: 2001

6. Retrospective analysis of 18 cases of antithyroid drug (ATD)-induced agranulocytosis.

Authors: Wei-Xin Dai; Jian-De Zhang; Shi-Wei Zhan; Bao-Zhen Xu; Hong Jin; Yang Yao; Wei-Chang Xin; Yao Bai
Journal: Endocr J Date: 2002-02 Impact factor: 2.349

7. Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood.

Authors: L Spahr; L Rubbia-Brandt; J Pugin; E Giostra; J L Frossard; B Borisch; A Hadengue
Journal: J Hepatol Date: 2001-11 Impact factor: 25.083

8. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial.

Authors: E Akriviadis; R Botla; W Briggs; S Han; T Reynolds; O Shakil
Journal: Gastroenterology Date: 2000-12 Impact factor: 22.682

9. Short- and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: a multicenter randomized trial.

Authors: E Cabré; P Rodríguez-Iglesias; J Caballería; J C Quer; J L Sánchez-Lombraña; A Parés; M Papo; R Planas; M A Gassull
Journal: Hepatology Date: 2000-07 Impact factor: 17.425

Review 10. Focus on: Alcohol and the liver.

Authors: Gyongyi Szabo; Pranoti Mandrekar
Journal: Alcohol Res Health Date: 2010

Current concepts and controversies in the treatment of alcoholic hepatitis.

1. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH.

2. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.

3. Burden of liver disease in the United States: summary of a workshop.

Review 4. Meta-analysis of propylthiouracil for alcoholic liver disease--a Cochrane Hepato-Biliary Group Review.

Review 5. S-adenosyl-L-methionine for alcoholic liver diseases.

6. Retrospective analysis of 18 cases of antithyroid drug (ATD)-induced agranulocytosis.

7. Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood.

8. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial.

9. Short- and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: a multicenter randomized trial.

Review 10. A model to predict survival in patients with end-stage liver disease.

1. Management of alcoholic hepatitis.

2. A meta-analysis of nutritional supplementation for management of hospitalized alcoholic hepatitis.

Review 3. Alcoholic hepatitis and HCV interactions in the modulation of liver disease.

Review 4. Alcoholic liver disease: pathogenesis and new therapeutic targets.

5. Transjugular liver biopsy in severe alcoholic hepatitis.

6. Pentoxifylline: a first line treatment option for severe alcoholic hepatitis and hepatorenal syndrome?

Review 7. Pentoxifylline for alcoholic hepatitis.

Review 8. Molecular targets in the treatment of alcoholic hepatitis.

9. Alcoholic hepatitis.

Review 10. Focus on: Alcohol and the liver.