Literature DB >> 17108190

Biology of circulating mRNA: still more questions than answers?

Michael Fleischhacker1.   

Abstract

A few years after the first description of free-circulating DNA in plasma and serum, the detection of tumor-associated overexpressed mRNA in plasma was also reported. This observation has been confirmed and it seems to be clear that the presence of free-circulating RNA is a ubiquitous phenomenon. In this short review I will discuss some basic aspects of the release mechanisms for the RNA, its biological meaning, and clinical value.

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Year:  2006        PMID： 17108190     DOI： 10.1196/annals.1368.005

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  6 in total

1.  Molecular characterization of human osteoblast-derived extracellular vesicle mRNA using next-generation sequencing.

Authors:  Jess Morhayim; Jeroen van de Peppel; Amel Dudakovic; Hideki Chiba; Andre J van Wijnen; Johannes P van Leeuwen
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2017-03-24       Impact factor: 4.739

Review 2.  cfRNAs as biomarkers in oncology - still experimental or applied tool for personalized medicine already?

Authors:  Tomasz Kolenda; Kacper Guglas; Dawid Baranowski; Joanna Sobocińska; Magda Kopczyńska; Anna Teresiak; Renata Bliźniak; Katarzyna Lamperska
Journal:  Rep Pract Oncol Radiother       Date:  2020-08-11

Review 3.  Development of blood biomarkers for drug-induced liver injury: an evaluation of their potential for risk assessment and diagnostics.

Authors:  David E Amacher; Shelli J Schomaker; Jiri Aubrecht
Journal:  Mol Diagn Ther       Date:  2013-12       Impact factor: 4.074

4.  Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes.

Authors:  F A San Lucas; K Allenson; V Bernard; J Castillo; D U Kim; K Ellis; E A Ehli; G E Davies; J L Petersen; D Li; R Wolff; M Katz; G Varadhachary; I Wistuba; A Maitra; H Alvarez
Journal:  Ann Oncol       Date:  2015-12-17       Impact factor: 32.976

5.  Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer.

Authors:  Kai Gao; Hui Zhou; Lei Zhang; Jin Wook Lee; Qing Zhou; Shen Hu; Lawrence E Wolinsky; James Farrell; Guido Eibl; David T Wong
Journal:  PLoS One       Date:  2009-06-11       Impact factor: 3.240

Review 6.  Circulating nucleic acids as biomarkers in breast cancer.

Authors:  Heidi Schwarzenbach
Journal:  Breast Cancer Res       Date:  2013       Impact factor: 6.466
  6 in total

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