Literature DB >> 17108041

Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism.

Mingli Qi1, Christopher Aiken.   

Abstract

The Nef protein enhances human immunodeficiency virus type 1 (HIV-1) infectivity by facilitating an early postentry step in the virus life cycle. We report here that the addition of MG132 or lactacystin, each a specific inhibitor of cellular proteasome activity, preferentially enhances cellular permissiveness to infection by Nef-defective versus wild-type HIV-1. Pseudotyping by the glycoprotein of vesicular stomatitis virus rendered Nef-defective HIV-1 particles minimally responsive to the enhancing effects of proteasome inhibitors. These results suggest that Nef enhances the infectivity of HIV-1 particles by reducing their susceptibility to proteasomal degradation in target cells.

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Year:  2006        PMID： 17108041      PMCID： PMC1797497          DOI： 10.1128/JVI.02099-06

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

1.  Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.

Authors:  C Aiken
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1.

Authors:  O Schwartz; V Maréchal; B Friguet; F Arenzana-Seisdedos; J M Heard
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

3.  Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: implications for HIV-based gene transfer systems.

Authors:  T Luo; J L Douglas; R L Livingston; J V Garcia
Journal:  Virology       Date:  1998-02-15       Impact factor: 3.616

4.  Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.

Authors:  M W Pandori; N J Fitch; H M Craig; D D Richman; C A Spina; J C Guatelli
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

5.  Nef increases infectivity of HIV via lipid rafts.

Authors:  Y H Zheng; A Plemenitas; T Linnemann; O T Fackler; B M Peterlin
Journal:  Curr Biol       Date:  2001-06-05       Impact factor: 10.834

6.  Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.

Authors:  M F Nunn; J W Marsh
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

7.  Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease.

Authors:  A A Bukovsky; T Dorfman; A Weimann; H G Göttlinger
Journal:  J Virol       Date:  1997-02       Impact factor: 5.103

8.  Identification of the Nef-associated kinase as p21-activated kinase 2.

Authors:  G H Renkema; A Manninen; D A Mann; M Harris; K Saksela
Journal:  Curr Biol       Date:  1999-12-02       Impact factor: 10.834

9.  Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase.

Authors:  R Welker; H Kottler; H R Kalbitzer; H G Kräusslich
Journal:  Virology       Date:  1996-05-01       Impact factor: 3.616

10.  Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions.

Authors:  Yong-Hui Zheng; Ana Plemenitas; Christopher J Fielding; B Matija Peterlin
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-24       Impact factor: 12.779
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  18 in total

1.  HIV: Antiviral action countered by Nef.

Authors:  Christopher Aiken
Journal:  Nature       Date:  2015-09-30       Impact factor: 49.962

2.  Nef enhances HIV-1 infectivity via association with the virus assembly complex.

Authors:  Mingli Qi; Christopher Aiken
Journal:  Virology       Date:  2008-01-14       Impact factor: 3.616

3.  The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild.

Authors:  Anke Heigele; Dorota Kmiec; Kerstin Regensburger; Simon Langer; Lukas Peiffer; Christina M Stürzel; Daniel Sauter; Martine Peeters; Massimo Pizzato; Gerald H Learn; Beatrice H Hahn; Frank Kirchhoff
Journal:  Cell Host Microbe       Date:  2016-09-14       Impact factor: 21.023

4.  Dendritic cell-mediated HIV-1 infection of T cells demonstrates a direct relationship to plasma viral RNA levels.

Authors:  Reetakshi Arora; Lara Bull; Edward B Siwak; Rajesh Thippeshappa; Roberto C Arduino; Jason T Kimata
Journal:  J Acquir Immune Defic Syndr       Date:  2010-06       Impact factor: 3.731

5.  Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant.

Authors:  Chisu Song; Christopher Aiken
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

6.  Quantitative analysis of human immunodeficiency virus type 1-infected CD4+ cell proteome: dysregulated cell cycle progression and nuclear transport coincide with robust virus production.

Authors:  Eric Y Chan; Wei-Jun Qian; Deborah L Diamond; Tao Liu; Marina A Gritsenko; Matthew E Monroe; David G Camp; Richard D Smith; Michael G Katze
Journal:  J Virol       Date:  2007-05-09       Impact factor: 5.103

7.  Cellular DNA repair cofactors affecting hepatitis B virus infection and replication.

Authors:  Fan Zhao; Ning-Bo Hou; Ting Song; Xiang He; Zi-Rui Zheng; Qing-Jun Ma; Li Li; Yan-Hong Zhang; Hui Zhong
Journal:  World J Gastroenterol       Date:  2008-08-28       Impact factor: 5.742

8.  Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses.

Authors:  Jan Münch; Devi Rajan; Michael Schindler; Anke Specht; Elke Rücker; Francis J Novembre; Eric Nerrienet; Michaela C Müller-Trutwin; Martine Peeters; Beatrice H Hahn; Frank Kirchhoff
Journal:  J Virol       Date:  2007-10-10       Impact factor: 5.103

9.  Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.

Authors:  Michael Schindler; Devi Rajan; Anke Specht; Carolin Ritter; Kati Pulkkinen; Kalle Saksela; Frank Kirchhoff
Journal:  J Virol       Date:  2007-09-19       Impact factor: 5.103

10.  Feline immunodeficiency virus OrfA alters gene expression of splicing factors and proteasome-ubiquitination proteins.

Authors:  Magnus Sundstrom; Udayan Chatterji; Lana Schaffer; Sohela de Rozières; John H Elder
Journal:  Virology       Date:  2007-10-25       Impact factor: 3.616
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