The amino acid sequence of an AL-protein, AL-KH, isolated from the heart of a patient with Waldenstroms macroglobulinemia and amyloidosis.

An AL-protein was isolated from the myocardium of a patient (KH) with Waldenstrom's macroglobulinemia. SDS-PAGE of the fraction revealed three major bands ranging from 14 to 30 kDa. Two of the major bands showed a positive PAS test for carbohydrate. The amino acid sequence was established for positions 1-92 and for positions 104-205, except for 150-187. According to the data, the AL-protein KH is derived from the kappa 1c germline gene.