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Literature DB >> 1710787

Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor.

Abstract

Neurokinin A, neurokinin B and substance P caused concentration-related contractions of rabbit isolated aorta with pD2 values of 8.1, 6.9, and 6.0, respectively. [D-Pro2, D-Trp7, 9]-substance P, a competitive tachykinin antagonist, had pA2 values of 5.3 against neurokinin A, 5.1 against neurokinin B and 5.2 against substance P indicating that tachykinin receptors mediated responses to the agonists. [pGlu5,MePhe8,-MeGly9]-substance P 5 - 11 (DiMe-C7), senktide and septide did not contract the aorta. It is concluded that of the known tachykinin receptors smooth muscle of the rabbit isolated aorta contains only the NK-2 type.

Entities: Chemical Species

Mesh：

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Year: 1990 PMID： 1710787 DOI： 10.1007/bf00175719

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

14 in total

1. Characterization of neurokinin receptors in various isolated organs by the use of selective agonists.

Authors: S Dion; P D'Orléans-Juste; G Drapeau; N E Rhaleb; N Rouissi; C Tousignant; D Regoli
Journal: Life Sci Date: 1987-11-16 Impact factor: 5.037

2. Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance P and related neurokinins.

Authors: P D'Orléans-Juste; S Dion; G Drapeau; D Regoli
Journal: Eur J Pharmacol Date: 1986-06-05 Impact factor: 4.432

Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor.

1. Characterization of neurokinin receptors in various isolated organs by the use of selective agonists.

2. Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance P and related neurokinins.

3. Desensitization with a selective agonist discriminates between multiple tachykinin receptors.

Review 4. New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization.

5. Pharmacological characterization of four related substance P antagonists.

6. Receptors for neurokinins in human bronchus and urinary bladder are of the NK-2 type.

7. Some quantitative uses of drug antagonists.

8. The contractile activities of neurokinin A, B and related peptides on smooth muscles.

9. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP.

10. Receptors for substance P. III. Classification by competitive antagonists.

1. Inhibition of tachykinin-induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors.