Literature DB >> 17107791

Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.

Kenneth M Meyers1, Nicholas Kim, José L Méndez-Andino, X Eric Hu, Rashid N Mumin, Sean R Klopfenstein, John A Wos, Maria C Mitchell, Jennifer L Paris, David C Ackley, Jerry K Holbert, Scott W Mittelstadt, Ofer Reizes.   

Abstract

Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.

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Year:  2006        PMID： 17107791     DOI： 10.1016/j.bmcl.2006.10.053

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  A general and efficient method for the Suzuki-Miyaura coupling of 2-pyridyl nucleophiles.

Authors:  Kelvin L Billingsley; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

2.  GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2.

Authors:  Justin R Nickell; Kiran B Siripurapu; David B Horton; Guangrong Zheng; Peter A Crooks; Linda P Dwoskin
Journal:  Eur J Pharmacol       Date:  2016-12-13       Impact factor: 4.432

3.  Iron oxide encapsulated by copper-apatite: an efficient magnetic nanocatalyst for N-arylation of imidazole with boronic acid.

Authors:  Othmane Amadine; Younes Essamlali; Abdallah Amedlous; Mohamed Zahouily
Journal:  RSC Adv       Date:  2019-11-11       Impact factor: 4.036
  3 in total

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