Literature DB >> 1710767

An endoplasmic reticulum-specific cyclophilin.

K W Hasel1, J R Glass, M Godbout, J G Sutcliffe.   

Abstract

Cyclophilin is a ubiquitously expressed cytosolic peptidyl-prolyl cis-trans isomerase that is inhibited by the immunosuppressive drug cyclosporin A. A degenerate oligonucleotide based on a conserved cyclophilin sequence was used to isolate cDNA clones representing a ubiquitously expressed mRNA from mice and humans. This mRNA encodes a novel 20-kDa protein, CPH2, that shares 64% sequence identity with cyclophilin. Bacterially expressed CPH2 binds cyclosporin A and is a cyclosporin A-inhibitable peptidyl-prolyl cis-trans isomerase. Cell fractionation of rat liver followed by Western blot (immunoblot) analysis indicated that CPH2 is not cytosolic but rather is located exclusively in the endoplasmic reticulum. These results suggest that cyclosporin A mediates its effect on cells through more than one cyclophilin and that cyclosporin A-induced misfolding of T-cell membrane proteins normally mediated by CPH2 plays a role in immunosuppression.

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Year:  1991        PMID： 1710767      PMCID： PMC361082          DOI： 10.1128/mcb.11.7.3484-3491.1991

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  49 in total

1.  Use of T7 RNA polymerase to direct expression of cloned genes.

Authors:  F W Studier; A H Rosenberg; J J Dunn; J W Dubendorff
Journal:  Methods Enzymol       Date:  1990       Impact factor: 1.600

2.  Nucleotide sequence of a cDNA coding for mouse cyclophilin.

Authors:  K W Hasel; J G Sutcliffe
Journal:  Nucleic Acids Res       Date:  1990-07-11       Impact factor: 16.971

3.  A C-terminal signal prevents secretion of luminal ER proteins.

Authors:  S Munro; H R Pelham
Journal:  Cell       Date:  1987-03-13       Impact factor: 41.582

4.  Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.

Authors:  E R Price; L D Zydowsky; M J Jin; C H Baker; F D McKeon; C T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

5.  Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis.

Authors:  J Liu; M W Albers; C M Chen; S L Schreiber; C T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

6.  Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.

Authors:  E A Emmel; C L Verweij; D B Durand; K M Higgins; E Lacy; G R Crabtree
Journal:  Science       Date:  1989-12-22       Impact factor: 47.728

Review 7.  Cyclosporin A: new insights for cell biologists and biochemists.

Authors:  R J Hohman; T Hultsch
Journal:  New Biol       Date:  1990-08

8.  Cyclophilin: a specific cytosolic binding protein for cyclosporin A.

Authors:  R E Handschumacher; M W Harding; J Rice; R J Drugge; D W Speicher
Journal:  Science       Date:  1984-11-02       Impact factor: 47.728

9.  Cyclosporin A slows collagen triple-helix formation in vivo: indirect evidence for a physiologic role of peptidyl-prolyl cis-trans-isomerase.

Authors:  B Steinmann; P Bruckner; A Superti-Furga
Journal:  J Biol Chem       Date:  1991-01-15       Impact factor: 5.157

10.  The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

Authors:  P S Mattila; K S Ullman; S Fiering; E A Emmel; M McCutcheon; G R Crabtree; L A Herzenberg
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598
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  43 in total

1.  Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.

Authors:  Guennadi Kozlov; Sara Bastos-Aristizabal; Pekka Määttänen; Angelika Rosenauer; Fenglin Zheng; April Killikelly; Jean-François Trempe; David Y Thomas; Kalle Gehring
Journal:  J Biol Chem       Date:  2010-08-27       Impact factor: 5.157

2.  Nucleotide sequence of a cDNA encoding an Arabidopsis cyclophilin-like protein.

Authors:  D Bartling; A Heese; E W Weiler
Journal:  Plant Mol Biol       Date:  1992-06       Impact factor: 4.076

3.  Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes.

Authors:  Shawna M Pyott; Ulrike Schwarze; Helena E Christiansen; Melanie G Pepin; Dru F Leistritz; Richard Dineen; Catharine Harris; Barbara K Burton; Brad Angle; Katherine Kim; Michael D Sussman; Maryann Weis; David R Eyre; David W Russell; Kevin J McCarthy; Robert D Steiner; Peter H Byers
Journal:  Hum Mol Genet       Date:  2011-01-31       Impact factor: 6.150

4.  Neurologic evaluation of acute lacrimomimetic effect of cyclosporine in an experimental rabbit dry eye model.

Authors:  Hiroshi Toshida; Doan H Nguyen; Roger W Beuerman; Akira Murakami
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-02-14       Impact factor: 4.799

5.  Protamine mRNA as molecular marker for spermatozoa in semen stains.

Authors:  M Bauer; D Patzelt
Journal:  Int J Legal Med       Date:  2003-02-04       Impact factor: 2.686

6.  Differential expression of cyclophilin isoforms during keratinocyte differentiation.

Authors:  D Chatellard-Gruaz; J H Saurat; G Siegenthaler
Journal:  Biochem J       Date:  1994-11-01       Impact factor: 3.857

7.  The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae.

Authors:  J Heitman; A Koller; J Kunz; R Henriquez; A Schmidt; N R Movva; M N Hall
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

8.  A cyclophilin from the polycentric anaerobic rumen fungus Orpinomyces sp. strain PC-2 is highly homologous to vertebrate cyclophilin B.

Authors:  H Chen; X L Li; L G Ljungdahl
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

9.  Purification and characterization of cytosolic and microsomal cyclophilins from maize (Zea mays).

Authors:  P S Sheldon; M A Venis
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857

10.  An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney.

Authors:  J Friedman; I Weissman; J Friedman; S Alpert
Journal:  Am J Pathol       Date:  1994-06       Impact factor: 4.307
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