Literature DB >> 17107100

Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl.LiCl.

Wenwei Lin1, Oliver Baron, Paul Knochel.   

Abstract

The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl.LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in >95%. After quenching, highly functionalized and substituted benzenes are obtained. [reaction: see text].

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Year:  2006        PMID： 17107100     DOI： 10.1021/ol0625536

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  12 in total

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