| Literature DB >> 17107082 |
Souichi Monma1, Toshiaki Sunazuka, Kenichiro Nagai, Takahiro Arai, Kazuro Shiomi, Ryosuke Matsui, Satoshi Omura.
Abstract
Verticilide (1) is a 24-membered cyclic depsipeptide isolated from the culture broth of Verticillium sp. FKI-1033. It inhibits ryanodine binding to ryanodine receptor (RyR) and has insecticidal activity. The stereochemistry of 2-hydroxyheptanoic acid in verticilide was elucidated by chiral HPLC analysis of the degradation product 6 and synthetic (+) and (-)-6. We also describe the practical total synthesis of verticilide. [reaction: see text].Entities:
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Year: 2006 PMID： 17107082 DOI： 10.1021/ol0623365
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005