| Literature DB >> 17107060 |
Alexandra K de K Lewis1, B James Mok, Derek A Tocher, Jonathan D Wilden, Stephen Caddick.
Abstract
A stereoselective one-pot synthesis of substituted 1,2-thiazetidine 1,1-dioxides (beta-sultams) has been achieved from heterocyclic pentafluorophenyl (PFP) sulfonates. Mild N-O bond cleavage of isoxazolidines followed by intramolecular cyclization of the amine onto the PFP demonstrates the potential utility for using the PFP sulfonate as a valuable precursor to sulfonamides. [reaction: see text].Entities:
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Year: 2006 PMID： 17107060 DOI： 10.1021/ol062164b
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005